| 胸腺肽治疗骨结核T淋巴细胞亚群变化的临床研究 |
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Received:November 19, 2003
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| 期刊信息：《中国骨伤》2004年17卷，第7期，第393-395页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
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目的:观察胸腺肽在骨结核治疗过程中T淋巴细胞亚群的变化,以期了解胸腺肽对于结核患者免疫功能的影响。
方法:将74例骨结核患者在正规抗结核治疗的基础上随机分为治疗组(加用胸腺肽组)、对照组,同时进行两组患者的T淋巴细胞亚群的动态检测。将所得数据进行统计分析,采用SPSS115统计软件进行数据处理。
结果:经3个月的治疗后,对照组T淋巴细胞亚群的改变与治疗前差异无显著性。而治疗组CD3+及CD4+升高、CD8+降低、CD4+/CD8+比值增高,均具有统计学意义(P<0.01)。
结论:胸腺肽对于骨结核患者免疫功能有一定的调节功能。 |
| [关键词]:胸腺肽 骨结核 T淋巴细胞亚群 |
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| Clinical study of the changes of T-lymphocyte sub-populations with the application of thymus peptide in the treatment of bone tuberculosis |
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Abstract:
Objective:To observe the change of T-lymphocyte sub-populations with the application of thymus peptide in the treatment of the patients with bone tuberculosis and to evaluate the effect of thymus peptide on immunity function of the patients.
Methods:74 patients were divided into therapy group(addition of thymus peptide group)and control group.Every patient was received the normal anti-TB treatment.In the initiation and end of the therapy,the variation data about T-lymphocyte sub-populations were checked and recorded.All data were analyzed with the statistical software of SPSS11.5.
Results:After three months,the changes of T-lymphocyte subsets in control group had no significant difference compared with pre-treatment.However,in therapy group CD3 +,CD4 + and CD4 +/CD8 + increased and CD8 + decreased compared to the pre-treatment ( P <0.01).
Conclusion:The application of thymus peptide can adjust immunity function effectively in bone tuberculosis patient. |
| KEYWORDS:Thymus peptide Tuberculosis of bone T-lymphocyte sub-populations |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 李运海,郑爱萍,梁冶矢,王秀达.胸腺肽治疗骨结核T淋巴细胞亚群变化的临床研究[J].中国骨伤,2004,17(7):393~395 |
| 英文格式: | LI Yun-hai,ZHENG Ai-ping,LIANG Ye-shi,WANG Xiu-da.Clinical study of the changes of T-lymphocyte sub-populations with the application of thymus peptide in the treatment of bone tuberculosis[J].zhongguo gu shang / China J Orthop Trauma ,2004,17(7):393~395 |
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