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脊髓损伤后脊髓自由基和超氧化物岐化酶的动态变化

Hits: 2400 Download times: 1461 Received:July 16, 2003

作者	Author	单位	Unit	E-Mail
郑望苟	ZHENG Wang-gou	武汉大学人民医院骨科,湖北武汉430060	Department of Orthopaedics,People’s Hospital of Wuhan University
潘卫红	PAN Wei-hong	华中科技大学同济医学院附属协和医院
郭卫春	GUO Wei-chun	武汉大学人民医院骨科,湖北武汉430060	Department of Orthopaedics,People’s Hospital of Wuhan University

期刊信息：《中国骨伤》2004年17卷，第7期，第391-392页

DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz

目的:研究脊髓损伤后脊髓内自由基丙二醛(MDA)含量及超氧化物岐化酶(SOD)的活性变化,以探讨自由基在脊髓继发性损伤中的作用机制。

方法:42只健康家兔采用改良式Allen氏法造成脊髓损伤模型,测定其损伤后12h、48h、3d、7d、14d及21d脊髓组织内自由基含量和超氧化物岐化酶的活性。

结果:脊髓损伤后,MDA在24h内显著升高,7d达最高峰,升幅达90%,并随之逐渐下降;伤后SOD活性显著下降,3d时达最低,降幅达54%,随后并逐渐回升。

结论:自由基和超氧化物歧化酶参与了脊髓继发性损伤的病理过程。

[关键词]:脊髓损伤自由基超氧化物岐化酶动物,实验

Dynamical changes of free radical and superoxide dissmutas after the experimental spinal cord injury in rats

Abstract:

Objective:To observe the active change of malonyldialdehyde (MDA)and superoxide dissmutas(SOD)contents in a series of intervals after acute spinal cord injury(SCI),and to study the free radical variation in secondary pathological damage of the spinal cord.

Methods:The SCI model in rabbits were made with modified Allen’s method.The amount of MDA and SOD of spinal cord tissue were determined in the 12 h , 48 h , 3 d ,7 d,14 d and 21 d after injury.

Results:The concentration of MDA significantly increased in the 24 h after SCI,reached the peak at the 7 d and then dropped down gradually.The activity of SOD significantly descended after SCI,was the lowest at 3 d and then return slightly.

Conclusion:This study suggested that free radical plays an important role in the secondary pathological damage of SCI.

KEYWORDS:Spinal injuries Free radical Superoxide dissmutas Animals,laboratory

引用本文，请按以下格式著录参考文献：

中文格式:	郑望苟,潘卫红,郭卫春.脊髓损伤后脊髓自由基和超氧化物岐化酶的动态变化[J].中国骨伤,2004,17(7):391~392
英文格式:	ZHENG Wang-gou,PAN Wei-hong,GUO Wei-chun.Dynamical changes of free radical and superoxide dissmutas after the experimental spinal cord injury in rats[J].zhongguo gu shang / China J Orthop Trauma ,2004,17(7):391~392

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