| 自体外周血干细胞与脱钙骨复合移植修复骨缺损的临床应用 |
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Received:September 17, 2003
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| 作者 | Author | 单位 | Unit | E-Mail |
| 刘淑恒 |
LIU Shu-heng |
安徽医科大学第一附属医院骨外科, 安徽合肥230032 |
Department of Orthopaedics,the 1st Affiliated Hospital of Anhui Medical University |
tianheng4959@sina.com |
| 董英海 |
DONG Ying-hai |
安徽医科大学第一附属医院骨外科, 安徽合肥230032 |
Department of Orthopaedics,the 1st Affiliated Hospital of Anhui Medical University |
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| 高学纯 |
GAO Xue-chun |
安徽医科大学第一附属医院骨外科, 安徽合肥230032 |
Department of Orthopaedics,the 1st Affiliated Hospital of Anhui Medical University |
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| 卜海富 |
BU Hai-fu |
安徽医科大学第一附属医院骨外科, 安徽合肥230032 |
Department of Orthopaedics,the 1st Affiliated Hospital of Anhui Medical University |
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| 朱如里 |
ZHU Ru-li |
安徽医科大学第一附属医院骨外科, 安徽合肥230032 |
Department of Orthopaedics,the 1st Affiliated Hospital of Anhui Medical University |
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| 张之栋 |
ZHANG Zhi-dong |
安徽医科大学第一附属医院骨外科, 安徽合肥230032 |
Department of Orthopaedics,the 1st Affiliated Hospital of Anhui Medical University |
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| 期刊信息：《中国骨伤》2004年17卷，第4期，第201-203页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:安徽省卫生厅科研基金资助课题(编号:卫科秘1998-105号);安徽省教育厅科研基金资助课题(编号:教科技1998-19号) |
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目的:观察自体外周血干细胞(APBSC)与脱钙骨(DBM)复合移植治疗良性骨肿瘤术后骨缺损的疗效。
方法:对12例骨肿瘤患者,手术切除骨肿瘤脱钙骨填充骨缺损,术后第7天行骨髓动员,每天皮下注射特尔立3.0μg/kg,连续3d,第4天静脉滴注10mg地塞米松后采集APBSC。在X线电视透视下将一枚骨穿针准确穿入骨缺损部位,然后抽取自体外周血干细胞即可注入骨缺损部位。通过术后连续X线片,了解其骨缺损修复能力。
结果:12例病人术后得到随访,时间为4～16个月,在2～4个月以内均开始有不同程度的骨化,成骨效应满意。
结论:自体外周血干细胞(APBSC)/脱钙骨(DBM)复合移植是一种治疗骨缺损有效的新方法。 |
| [关键词]:移植,造血干细胞 脱钙骨 骨肿瘤 骨缺损 |
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| Clinical application in repair of bony defects by grafting of autologous peripheral blood stem cell combine with demineralized bone matrix |
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Abstract:
Objective: To observe the effect of repairing segmental bony defects by the grafting of autologous peripheral blood stem cells (APBSC) and demineralized bone matrix (DBM).
Methods: 12 patients were reported,the bony defects of the benign bone tumors resections were repaired by DBM,marrow mobilization at 7 days postoperatively,GM-CSF 3.0 μg/kg was subcutaneously injected daily for 3 days.On the 10th day,APBSC were harvested on the 3rd hour after intravenous adminstration of 10mg dexamethasome.A marrow needle was inserted into the site of the bone defects under the X-ray,APBSC were aspirated and injected immediately into the site of bone defects.The ability of repairing segmental bony defects were observed with serial radiography.
Results: 12 cases were followed up from 4 to 16 months after operation.All the cases healed primaily,variously degrees of ossification were found in the cases from 2 to 4 months after operation.
Conclusion: APBSC/DBM is a effective and new method for the repair of bony defects. |
| KEYWORDS:Transplantation,hematopoietic stem cell Demineralized bone Bone neoplasm Bone defect |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 刘淑恒,董英海,高学纯,卜海富,朱如里,张之栋.自体外周血干细胞与脱钙骨复合移植修复骨缺损的临床应用[J].中国骨伤,2004,17(4):201~203 |
| 英文格式: | LIU Shu-heng,DONG Ying-hai,GAO Xue-chun,BU Hai-fu,ZHU Ru-li,ZHANG Zhi-dong.Clinical application in repair of bony defects by grafting of autologous peripheral blood stem cell combine with demineralized bone matrix[J].zhongguo gu shang / China J Orthop Trauma ,2004,17(4):201~203 |
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