| 外用中药对兔创面表皮细胞生长因子的影响 |
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Received:September 02, 2003
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| 期刊信息：《中国骨伤》2004年17卷，第3期，第135-137页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:浙江省中医药管理局资助课题 (2000C16) |
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目的:探讨外用中药对白兔创面愈合不同时期肉芽组织中表皮细胞生长因子(EGF)的影响与创面愈合之间的关系。
方法:采用手术方法造成背部的深创面白兔85只。随机分成愈创膜组、生肌愈皮膏组和凡士林组。3组创面分别应用相应药物治疗。分别于术后第3、5、7、11、15天,以放射免疫法测定创面肉芽组织EGF含量。
结果:术后第3、5、7天,2个中药组创面肉芽组织中EGF含量均高于凡士林组(P<0.01)。且2个中药组第5天时EGF含量均达到整个愈合过程中的峰值,在第7天时仍保持高浓度。而凡士林组第7天时才达到高峰。第11、15天时3组EGF含量逐渐减少,各时间点2个中药组间比较差异无显著性意义(P>0.05)。
结论:愈创膜及生肌愈皮膏均能增加早、中期白兔创面肉芽组织的EGF含量,从而加快创面的愈合。 |
| [关键词]:表皮生长因子 中草药 伤口愈合 |
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| Effect of the external use of Chinese traditional medicine on EGF of rabbit wound |
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Abstract:
Objective:To investigate the relation between the effect of the external use of Chinese medicine on EGF of granulation tissue in rabbit wound and wound healing.
Methods:Under the same condition,the experimental deep wound models of 85 rabbits were created by surgical operation.The wounds were divided into three groups:Yuchuang film group(Group M),Shengji Yupi ointment group(Group G) and Vaseline group(Group F).In different healing phrase,the EGF protein content in the granulation tissue of rabbit’s wound was measured by radioimmune method.
Results:In the 3rd,5th and 7th days,the EGF protein contents in the wounds of Group M and Group G were more than those in the wounds of Group F (P<0.01).In the 5th day,the EGF contents in the wounds of Group M and Group G got to the top content during the whole healing,2 days earlier than those in the wounds of Group F.In the 11th and 15th days,the EGF contents of the three groups were all decreased.In every observing day,there was not obvious difference between Group M and Group G (P>0.05).
Conclusion:Yuchuang film and Shengji Yupi ointment can both accelerate wound healing through increasing the EGF protein contents of rabbit wounds in the early and middle phrase of wound healing. |
| KEYWORDS:Epidermal growth factor Drugs,Chinese herbal Wound healing |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 董黎强,章明,王维佳.外用中药对兔创面表皮细胞生长因子的影响[J].中国骨伤,2004,17(3):135~137 |
| 英文格式: | DONG Li qiang,ZHANG Ming,WANG Wei jia.Effect of the external use of Chinese traditional medicine on EGF of rabbit wound[J].zhongguo gu shang / China J Orthop Trauma ,2004,17(3):135~137 |
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