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颈椎失稳所致心肌缺血家兔心肌超微结构的观察

Hits: 2681 Download times: 1373 Received:March 04, 2003

作者	Author	单位	Unit	E-Mail
齐越峰	QI Yue-feng	北京市丰盛中医骨伤专科医院,北京100032	Fengsheng Hospital of Orthopacdics and Traumatology of TCM
张军	ZHANG Jun	中国中医研究院骨伤科研究所
孙树椿	SUN Shu-chun	中国中医研究院骨伤科研究所
付宝弛	FU Bao-chi	抚顺市第三医院

期刊信息：《中国骨伤》2004年17卷，第1期，第7-9页

DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz

目的:探讨颈椎错位失稳对缺血心肌超微结构改变的影响。

方法:通过手术切断C₅～C₆、C₆～C₇、C₇～T₁的棘间韧带,旋转错位C₆和C₇椎体,建立颈椎错位失稳模型。分别在术后1、2、3个月时采用透射电镜观察缺血心肌细胞超微结构的改变情况。

结果:术后1个月心肌细胞无明显改变,术后2、3个月时,心肌细胞的膜性细胞器出现了明显的病理损害,肌丝松散、线粒体肿胀,内嵴损害,糖原颗粒减少,这些表现随着时间的推移逐渐加重。

结论:颈椎长期失稳可引起缺血心肌出现器质性损害;颈椎病可能为冠心病的一个重要病因。

[关键词]:颈椎病心肌缺血动物,实验

Observation on ultrastructure of ischemic myocardium in rabbits with cervical vertebral instability

Abstract:

Objective:To inquire into influence of cervical vertebral instability on the ultrastructure of ischemic myocardium.

Methods:Animal models were made by cutting off supraspinal ligaments of C₅～C₆, C₆～C₇, C₆～T₁,ratating and displacing C₆～C₇ vertebral bodies.The changes of ultrastructure of ischemic myocardium were observed with electrical microscope at 1,2,3 months after the operation.

Results:At 1 month after operation,no changes were found.But at 2,3 months after operation,pathologic changes of myocardial cell,such as areosis of myofilament,mitochondrial swelling,quantity of crista decreased,were found,which gradually aggravated along with time.

Conclusion:Long-term cervical vertebral instability could induce organic damage of ischemic myocardium.Cervical spondylosis may be an important factor of coronary heart disease.

KEYWORDS:Cervical spondylosis Myocardial infarction Animals,laboratory

引用本文，请按以下格式著录参考文献：

中文格式:	齐越峰,张军,孙树椿,付宝弛.颈椎失稳所致心肌缺血家兔心肌超微结构的观察[J].中国骨伤,2004,17(1):7~9
英文格式:	QI Yue-feng,ZHANG Jun,SUN Shu-chun,FU Bao-chi.Observation on ultrastructure of ischemic myocardium in rabbits with cervical vertebral instability[J].zhongguo gu shang / China J Orthop Trauma ,2004,17(1):7~9

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