| 中药骨康预防去势大鼠骨质疏松症的血清IL-6、E2和BGP含量的影响 |
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Received:March 12, 2003
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| 作者 | Author | 单位 | Unit | E-Mail |
| 余阗 |
YU Tian |
深圳市中医院,广东 深圳 518033 |
Shenzhen Hospital of TCM Guangdong Shenzhen, 518033, China |
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| 刘庆思 |
LIU Qingsi |
广州中医药大学 |
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| 卿茂盛 |
QING Maosheng |
深圳市中医院,广东 深圳 518033 |
Shenzhen Hospital of TCM Guangdong Shenzhen, 518033, China |
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| 陈小砖 |
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深圳市中医院,广东 深圳 518033 |
Shenzhen Hospital of TCM Guangdong Shenzhen, 518033, China |
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| 黎杰运 |
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深圳市中医院,广东 深圳 518033 |
Shenzhen Hospital of TCM Guangdong Shenzhen, 518033, China |
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| 喻永新 |
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广州市越秀区正骨医院 |
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| 熊学华 |
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广州军区海军医院 |
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| 期刊信息：《中国骨伤》2003年16卷，第12期，第729-730页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
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目的:探讨补肾活血类中药骨康预防去势大鼠骨质疏松症的作用。
方法:本实验研究建立了切除卵巢诱发绝经后骨质疏松症的清洁级SD大鼠模型,运用随机对照分组原则,以血清IL-6、E2和BGP含量指标,观察骨康预防去势大鼠骨质疏松的作用。
结果:给药4个月后各组大鼠血清雌二醇含量差异有显著性意义,各组均明显高于模型组,正常组、骨康组、阳性组比较无明显差异。各组大鼠血清骨钙素含量差异有显著性意义,各组均明显高于模型组,骨康组明显高于正常组,而阳性组又明显高于骨康组。各组大鼠血清IL-6在给药后4个月差异有显著性意义,各组均明显低于模型组。
结论:骨康能有效提高去势大鼠体内雌二醇、骨钙素含量,降低体内IL-6含量,具有抑制骨吸收和促进骨形成的双重作用。 |
| [关键词]:骨质疏松 绝经后 中药疗法 白细胞介素6 雌二醇 骨钙素 |
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| Effect of Gukang on the content of IL-6, E2 and BGP in the serum of ovariectomized rats with osteoporosis |
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Abstract:
Objective:To probe into the effects of Gukang, which is composed of kidney tonifying and blood-circulation-activating herbal medicine, on the prevention from osteoporosis of ovariectomized rats with serologic target. Method Forty eight rats were divided randomly into four groups:normal group,model group, Gukang group and Estradiol group. The serologic parameters were Interleukin-6 (IL-6), Estradiol (Dihy-drotheelin)(E2) ,Bone Gelation protein (BGP). Result The Estradiol and BGP in other groups were higher than that in model group;the IL-6 in other groups were significantly lower than that in model group,but there were no significant difference among Gukang group,Estradiol group and normal group.
Conclusion:Gukang can promote the Estradiol and BGP in rats with osteoporosis,decrease IL-6 in rats with osteoporosis. Gukang possesses the double function of inhibition of bone absorbtion and acceleration of osteogenesis. |
| KEYWORDS:Osteoporosis,postmenopausal Treatment with Chinese herbs Interleukin-6 Estra-diol Osteo-calciun |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 余阗,刘庆思,卿茂盛,陈小砖,黎杰运,喻永新,熊学华.中药骨康预防去势大鼠骨质疏松症的血清IL-6、E2和BGP含量的影响[J].中国骨伤,2003,16(12):729~730 |
| 英文格式: | YU Tian,LIU Qingsi,QING Maosheng.Effect of Gukang on the content of IL-6, E2 and BGP in the serum of ovariectomized rats with osteoporosis[J].zhongguo gu shang / China J Orthop Trauma ,2003,16(12):729~730 |
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