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骨髓方治疗慢性骨髓炎的实验研究
Hits: 1960   Download times: 1368   Received:September 26, 2002    
作者Author单位UnitE-Mail
刘献祥 LIU Xianxiang 福建中医学院骨伤系,福建福州350003 Department of Traumatology &
Orthopaedics of Fujian TCM, Fujian Fuzhou 350003
 
刘伯龄 LIU Boling 福建中医学院骨伤系,福建福州350003  
周琳瑛 ZHOU Linying 福建医科大学  
期刊信息:《中国骨伤》2003年16卷,第6期,第340-342页
DOI:doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz
基金项目:福建省卫生厅科研基金资助项目 (202 )


目的:观察骨髓方治疗大鼠慢性骨髓炎的疗效。

方法:采用SD大鼠建立慢性骨髓炎模型,随机分成四组:骨髓方Ⅰ组、骨髓方Ⅱ组、对照组和空白组。治疗1个月,观察WBC、RBC、E-C3bRR、E-ICR、血清溶菌酶含量、骨X线、病理组织学指标。

结果:骨髓方Ⅰ、Ⅱ组与空白组差异有非常显著性(P<0.01);RBC、E-C3bRR、E-ICR、血清溶菌酶含量指标骨髓方Ⅰ、Ⅱ组明显优于对照组(P<0.01)。光镜下病理组织学观察骨髓方Ⅰ、Ⅱ组明显优于对照组和空白组;电镜下,骨髓方Ⅰ、Ⅱ组细胞结构受损程度小于对照组和空白组。

结论:骨髓方治疗慢性骨髓炎有较好疗效,提示与其提高机体免疫力、促进微循环和促进成骨有关。
[关键词]:骨髓炎  中草药  动物,实验  
 
Experimental study on the treatment of chronic osteomyelitis with bone marrow decoction
Abstract:

Objective: To observe the effects of bone marrow decoction on chronic osteomyelitis in rat model

Methods: SD rats animals with chronic osteomyelitis were randomly divided into four groups:bone marrow group Ⅰ,bone marrow group Ⅱ,control group and blank group.All animals were treated for 1 month and observed with WBC,RBC,Erythrocyte C3b receptor ratio(E-C3bRR),erythrocyte immune compound ratio(E-ICR),serum lysozyme activity,bone X-ray and histopathological index.

Results: There were significant difference between the bone marrow group Ⅰ/Ⅱ and blank group(P<0.01).Comparison between the bone marrow group Ⅰ/Ⅱ and blank group shown that RBC,E-C3bRR,E-ICR and serum lysozyme activity were significantly better(P<0.01).In respects of roentgenography and histological manifestation,bone marrow group were better than the control group and the blank group;The injury degree to the cell structure of bone marrow group were less than the control group and the blank group

Conclusion: Extractant from bone marrow decoction have good effects on chronic osteomyelities in rat model,which suggest that bone marrow decoction can improve the immune function,the histological microenvironment and repairing of bone.
KEYWORDS:Chronic osteomyelitis  Drugs,Chinese herbal  Animals,laboratory
 
引用本文,请按以下格式著录参考文献:
中文格式:刘献祥,刘伯龄,周琳瑛.骨髓方治疗慢性骨髓炎的实验研究[J].中国骨伤,2003,16(6):340~342
英文格式:LIU Xianxiang,LIU Boling,ZHOU Linying.Experimental study on the treatment of chronic osteomyelitis with bone marrow decoction[J].zhongguo gu shang / China J Orthop Trauma ,2003,16(6):340~342
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