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椎动脉型颈椎病患者中缩血管活性肽类物质的变化及意义

Hits: 2523 Download times: 1435 Received:December 04, 2002

作者	Author	单位	Unit	E-Mail
杜协彬	DU Xibin	普宁华侨医院骨科,广东普宁515300	Department of Orthopaedics,Puning Huaqiao Hospital Guandong Puning 515300
张军	ZHANG Jun	中国中医研究院骨伤科研究所
齐越峰	QI Yuefeng	中国中医研究院骨伤科研究所
许锐		普宁华侨医院骨科,广东普宁515300
朱吉武		辽宁省抚顺市第三医院
孙树椿		中国中医研究院骨伤科研究所

期刊信息：《中国骨伤》2003年16卷，第5期，第262-263页

DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz

基金项目:国家科技部资助项目(96-901-01-87)

目的:探索缩血管活性肽类物质在椎动脉型颈椎病发病时的变化情况及病理意义。

方法:椎动脉型颈椎病治疗组30例,正常组30例,椎动脉型颈椎病患者均采用中医手法治疗。正常组和治疗组患者分别在治疗前和治疗后空腹取静脉血进行神经肽类物质NPY、ET、CGRP、ANP放射免疫检测。

结果: 治疗前椎动脉型颈椎病患者的血浆NPY、ET、ANP明显高于正常组,而CGRP的含量则低于正常组(P<0.05);经过治疗后患者的血浆NPY、ET、ANP含量降低,CGRP的含量升高,与治疗前比较具有显著性差异(P<0.05)。

结论:缩血管活性肽类物质在椎动脉型颈椎病发病时可能起重要的神经体液调节作用。

[关键词]:颈椎病椎动脉供血不足神经肽

Changes and significance of neuropeptide in cervical spondylosis of vertebral artery type

Abstract:

Objective:To Explore changes and significance of neuropeptide in cervical spondylosis of vertebral artery type(CSA)

Methods:NPY,ET,CGRP and ANP were measured with radio immunity Methods in 30 cases of CSA treated with massage and 30 normal volunterr.

Results:Before treating,NPY,ET and ANP in CSA cases were higher than those in normal group,but CGRP vas contrary(P<0.05).After treating,NPY?ET and ANP were lowered,while CGRP increased compared with pre treating(P<0.05).

Conclusion:NPY,ET,CGRP and ANP may play important role in regulation of nerve and fluid function of CSA.

KEYWORDS:Cervical spondylosis Vertebrobasilar artery insufficiency Neuropeptide

引用本文，请按以下格式著录参考文献：

中文格式:	杜协彬,张军,齐越峰,许锐,朱吉武,孙树椿.椎动脉型颈椎病患者中缩血管活性肽类物质的变化及意义[J].中国骨伤,2003,16(5):262~263
英文格式:	DU Xibin,ZHANG Jun,QI Yuefeng.Changes and significance of neuropeptide in cervical spondylosis of vertebral artery type[J].zhongguo gu shang / China J Orthop Trauma ,2003,16(5):262~263

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