| BMP和TGF-β对兔尺骨骨缺损修复作用的研究 |
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Received:April 10, 2002
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| 期刊信息：《中国骨伤》2003年16卷，第3期，第148-151页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:重庆市科委应用基础研究基金;太极医学科技基金资助项目(2000177) |
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目的:探讨外源性BMP和TGF-β对骨缺损的修复作用。
方法:采用兔尺骨干15cm缺损模型,在骨缺损局部单独或联合应用TGF-β和BMP,在4、8、12周三个时相点进行大体形态观察、组织学、X线片观察和在12周时进行生物力学测试,对骨缺损修复效果进行评估。
结果BMP和/或TGF-β治疗组骨缺损均已修复,对照组骨缺损未修复,联合应用TGF-β和BMP的修复效果明显优于单用TGF-β或BMP,而BMP又优于TGF-β;在生物力学方面,TGF-β和BMP复合应用的力学强度与正常骨接近,单独应用时明显弱于正常骨,TGF-β弱于BMP。
结论:BMP和TGF-β对骨缺损均具有一定的修复作用,BMP的作用强于TGF-β,复合应用时,二者作用进一步增强,在修复骨缺损方面具有协同作用。 |
| [关键词]:骨形态发生蛋白 转化生长因子β 骨缺损 骨修复 |
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| The effects of exogenous bone morphogenetic protein and transforming growth factor-beta on repairing ulna defects in rabbits |
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Abstract:
Objective:To investigate the effects of exogenous bone morphogenetic protein (BMP) and transforming growth factor beta (TGF-β) on repairing bone defects
Methods:Adult rabbits were inflicted with the model of 1 5 cm segmental defect in the right ulna and treated locally with TGF-β and BMP,alone or in combination in the bone defect site.The repair capability was evaluated by gross,histological and radiographic examinations at the 4th,8th and 12th week and by biomechanical tests at the 12th week after operation.
Results:The bone defects were all repaired in the treatment groups,which could not be found in the control group.The repair was better in co treatment group with TGF-β and BMP than in treatment groups with TGF-β or BMP alone respectively,whereas BMP group was better than TGF-β group.The biomechanical strength of the ulna in the co treatment group with BMP and TGF-β was approached to that of normal bone,whereas that of treatment alone with BMP or TGF-β was weaker than normal bone and TGF-β group was weaker than BMP group.
Conclusion:BMP and TGF-β could promote repair of segmental bone defects and the effect of BMP is better than that of TGF-β.It has been observed co treatment with BMP and TGF-β can enhance further this effect and their interact with each other to modulate cooperatively and synergistically repairing bone defects. |
| KEYWORDS:Bone morphogenetic protien (BMP) Transforming growth factor beta (TGF-β) Bone defect Bone repair |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 卢卫忠,贺小兵,唐康来,杨柳,朱庆和,刘小冬,何静,许建中,吴梅英.BMP和TGF-β对兔尺骨骨缺损修复作用的研究[J].中国骨伤,2003,16(3):148~151 |
| 英文格式: | LU Weizhong,HE Xiaobing,TANG Kanglai.The effects of exogenous bone morphogenetic protein and transforming growth factor-beta on repairing ulna defects in rabbits[J].zhongguo gu shang / China J Orthop Trauma ,2003,16(3):148~151 |
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