| 骨折端Ⅷ因子相关抗原与血流量的实验研究 |
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Received:May 15, 2002
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| 期刊信息：《中国骨伤》2003年16卷，第1期，第17-19页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:国家重点基础研究发展规划资助项目(G1999054204) |
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目的：研究骨折愈合过程中骨折端Ⅷ因子相关抗原和血流量变化的规律及其相关性。
方法：选用35只大耳白兔制作左侧桡骨骨折动物模型,分别于伤后8、24、72h,1、3、5、8周利用单光子放射计算机断层显像术(SinglePhotonEmissionComputerizedTomography,SPECT)测定骨折端血流量变化,之后取骨折端标本提取蛋白样本定量检测Ⅷ因子相关抗原。
结果：骨折端血流量在致伤后8h开始上升,1周时达顶峰,高血流量状态一直维持到第3周,第5和第8周基本恢复到正常水平；骨折端Ⅷ因子相关抗原在伤后24h开始增高,骨折后3天达到较高的水平,该状态一直维持到骨折后的第3周,到第5周时开始出现较明显的回落,第8周时基本恢复到正常水平。
结论：伤后72h骨折端血流量增高与骨折端血管生成有关,早期的血流量增加可能与骨折后的创伤反应有关。 |
| [关键词]:骨折愈合 因子Ⅷ相关抗原 血流量 |
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| An experimental study of the correlation of blood coagulation factor Ⅷ-related antigen and blood flow at the fracture ends |
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Abstract:
Objective:To study the changing pattern and correlation of blood coagulation factor Ⅷ-related antigen and blood flow at the fracture ends in the process of fracture healing
Methods:Thirty five rabbits were selected to establish the fracture model at the left radius;the blood flow was estimated by single photon emission computerized tomography (SPECT) at different intervals (8th,24th,72th hour,1st,3rd,5th,8th week)after fracture,then the specimens were taken to procure protein for assay the changing blood coagulation factor Ⅷ-related antigen.
Results:The blood flow began to increase at the 8th hour after fracture and reached the peak on the lst week;the condition of high blood flow kept to the third week and dropped to normal level at the 5th and 8th week after fracture.Factor Ⅷ-related antigen began to increase at the 24th hour after fracture and reached to a higher level at the 72th hour;this state was kept to the 3rd week.The factor Ⅷ-related antigen obviously decreased at the 5th week after fracture and dropped to the normal at the 8th week.
Conclusion:The increase of blood flow at fractured sits is related to the angiogenesis after fracture in 72 hours,the increasing of blood flow within 3 days may be related to the traumatic reaction. |
| KEYWORDS:Fractures healing Factor Ⅷ-related antigen Blood flow |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 初同伟,王正国,朱佩芳,焦文仓,温建良.骨折端Ⅷ因子相关抗原与血流量的实验研究[J].中国骨伤,2003,16(1):17~19 |
| 英文格式: | CHU Tongwei,WANG Zhengguo,ZHU Peifang.An experimental study of the correlation of blood coagulation factor Ⅷ-related antigen and blood flow at the fracture ends[J].zhongguo gu shang / China J Orthop Trauma ,2003,16(1):17~19 |
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