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葛根汤对大鼠退变颈椎间盘组织前列腺素E₂及环氧合酶的影响

Hits: 2220 Download times: 1318 Received:June 03, 2002

作者	Author	单位	Unit	E-Mail
周军	ZHOU Jun	中国中医研究院中药研究所,北京 100700	Institute of Chinese Materia Medica, China Academy of TCM Beijing, 100700, China
方素萍	FANG Su-ping	北京广安门医院分子生物室
霍海如	HUO Hai-ru	中国中医研究院中药研究所,北京 100700	Institute of Chinese Materia Medica, China Academy of TCM Beijing, 100700, China
齐云		中国中医研究院中药研究所,北京 100700	Institute of Chinese Materia Medica, China Academy of TCM Beijing, 100700, China
郭淑英		中国中医研究院中药研究所,北京 100700	Institute of Chinese Materia Medica, China Academy of TCM Beijing, 100700, China
姜廷良		中国中医研究院中药研究所,北京 100700	Institute of Chinese Materia Medica, China Academy of TCM Beijing, 100700, China
施杞		上海中医药大学骨伤所

期刊信息：《中国骨伤》2002年15卷，第12期，第724-726页

DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz

基金项目:国家95攀登预选项目“中药现代化关键问题的基础研究”课题(970211018)

目的:观察葛根汤对模型大鼠退变颈椎间盘组织PGE₂及COX活性的影响,以探讨葛根汤治疗颈椎病的抗炎作用机理。

方法:选用动力失衡性颈椎病动物模型,造模后6个月,取出颈椎间盘组织,采用放免法、催化活性测定法分别测定PGE₂含量及COX活性。

结果: 模型组PGE₂含量及COX活性明显升高,葛根汤可下调PGE₂的含量及抑制COX的活性。

结论:葛根汤下调退变颈椎间盘组织中PGE2的含量,与抑制COX活性密切相关,这可能是其治疗颈椎病的作用机制之一。

[关键词]:中草药颈椎病前列素E2 环氧合酶

Effects of GeGen Decoction on PGE2 and COX in degenarated cervical intervertebral discs in rats

Abstract:

Objective:To explore the anti-inflammation mechanism of GeGen Decoction (GGD) on cervical spondylosis by investigating GGD on Prostaglandin E₂(PGE₂) and Cyclooxygenase (COX) activity in degenerated cervical intervertebral discs

Methods:Rats were modeled on the cervical dynamic unbalance, and 6 months later PGE2 content and COX activity in cervical intervertebral discs were measured by radioim-munoassay and catalytic activity assay, respectively.

Results:The PGE₂ and COX activity were significantly higher in experimental groups;GGD could down-regulate the content of PGE₂ and inhabit COX activity.

Conclusion:GGD could down-regulate the content of PGE₂ activity in degenerated cervical intervertebral discs by inhabit COX activity, which may be one of its mechanisms in treating cervical spondylosis.

KEYWORDS:Chinese herbal drugs Cervical vertebrae disease Prostaglandin E2 Cyclooxygenase

引用本文，请按以下格式著录参考文献：

中文格式:	周军,方素萍,霍海如,齐云,郭淑英,姜廷良,施杞.葛根汤对大鼠退变颈椎间盘组织前列腺素E₂及环氧合酶的影响[J].中国骨伤,2002,15(12):724~726
英文格式:	ZHOU Jun,FANG Su-ping,HUO Hai-ru.Effects of GeGen Decoction on PGE2 and COX in degenarated cervical intervertebral discs in rats[J].zhongguo gu shang / China J Orthop Trauma ,2002,15(12):724~726

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