| 甲壳素-聚己内酯复合接骨板的实验研究 |
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Received:November 17, 2001
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| 期刊信息：《中国骨伤》2002年15卷，第11期，第666-667页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
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目的:观察生物接骨板植入周围的组织对接骨板的反应。
方法:实验组用甲壳素聚己内酯复合材料制成的生物接骨板及螺钉,包埋于28只兔右胫骨中段;在8只兔的对照组中,于相应部位植入金属钢板。实验组动物于术后2、4、6、8、12、24、36周处死,其中24、36周组在处死前行ECT检查;对照组于术后4、8周时分别处死,处死前行ECT检查,观察植入局部反应情况。所有实验动物均行病理切片观察局部组织的反应。
结果:实验组组织学表现为术后2周有较明显的炎症反应,4周组更明显,此后逐渐减弱,24及36周组炎性细胞未见;各组均可观察到新生骨小梁。对照组炎症反应不明显,未观察到新生骨小梁。ECT显示放射性核素在生物接骨板周围明显浓集,对照组未观察到同样现象。
结论:生物接骨板在体内可引起较明显的无菌性炎症反应,但随着时间的延长,炎症反应逐渐减弱,在36周时基本消失。 |
| [关键词]:内固定 甲壳素聚己内酯接骨板 材料试验 |
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| An experimental study of Chitin-Polycaprolactone bone plate |
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Abstract:
Objective:To investigate the adjacent tissue reaction to the biological bone plate
Methods:In the experimemt group,the bone plates and bolts,made of chitin & polycaprolactone,were embeded in the middle segment of the right tibia of rabbits.The follow up periods were 2,4,6,and 12,24,36 weeks after operation.Before sacrifice of the animals at the 24,36 weeks,ECT was carried out in order to observe the osteogenesis reaction.In the control group,the metallic bone plates and bolts were used.The follow up times were 4 and 8 weeks.ECT was also done.to observe the local tissue reaction to the bone plates.
Results:In the experimental group,histology showed remarkable inflammation two weeks after operation,and more severe by the 4 weeks,then lessened gradually.The inflammation reaction was not seen by the end of 36 weeks.Osteogenesis reaction could be observed showing newly grown bone trabeculae.In the control group,there was no osteogenesis reaction.From the ECT examination,it was observed that Radionuclide concentrated around the biological bone plate in the experimental group,but the same phenomena was not observed in the control group.
Conclusion: The biological bone plates and bolts would cause obviouslv sterile inflammatorvy reaction in some cases at earlier period,but it would decrease as time goes by.It could induce the osteogenesis reaction. |
| KEYWORDS:Internal fixator Chitin Polycaprolactone bone plate Materials testing |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 高招文,赵建宁,陆维举,张新华,朱虹,马恒辉.甲壳素-聚己内酯复合接骨板的实验研究[J].中国骨伤,2002,15(11):666~667 |
| 英文格式: | GAO Zhao wen,ZHAO Jian ning,LU Wei ju.An experimental study of Chitin-Polycaprolactone bone plate[J].zhongguo gu shang / China J Orthop Trauma ,2002,15(11):666~667 |
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