| 大鼠不同部位骨骼对外源性甲状腺激素反应性的研究 |
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Received:January 10, 2002
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| 期刊信息：《中国骨伤》2002年15卷，第9期，第534-536页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:中华医学基金会医学师资奖学金 (CMB)资助 |
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目的:用左旋甲状腺素(LT4)制备实验性甲状腺功能亢进(甲亢)大鼠模型,以探讨甲亢大鼠的胫骨和椎骨对外源性甲状腺激素的反应性,为临床监测长期LT4治疗提供依据。
方法:9周龄雄性SpragueDawley(SD)大鼠18只,随机分为甲亢组11只、对照组7只。甲亢组予LT4腹腔内注射,对照组予生理盐水注射,连续注射3周后取大鼠的胫骨近端、第四腰椎用非脱钙骨组织形态计量法进行同期观察和研究。
结果:在胫骨甲亢组的骨小梁数量降低,骨形成表面、吸收表面均增加,但骨吸收表面增加更明显,骨小梁平均宽度、骨纵向生长率降低,而骨矿化率增加。椎骨未观察到此变化。
结论:LT4引起继发性胫骨骨量减少,骨转换增加,椎骨无反应,表明不同部位的骨骼对甲状腺激素的反应存在异质性。 |
| [关键词]:甲状腺激素 骨组织形态计量学 骨质疏松 |
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| Responses in different skeletal sites of the rats to exogenous thyroid hormone |
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Abstract:
Objective:To determine the skeletal response in different sites to exogenous thyroid hormone in rat models of hyperthyroidism by administrating levo thyroxine(L T4)
Methods:18 male Sprague Dawley (SD) rats of 9 weeks old were randomly divided into hyperthyroid group (n=11) and control group (n=7).After 3 weeks of L T4 treatment of hyperthyroid group,histomorphometric parameters of trabecular bone remodeling were assessed in the proximal tibia and in the fourth vertebra.
Results:In tibia,trabecular bone volumes,mean trabecular thickness,and longtitudinal bone growth rate were decreased,trabecular formation surfaces and resorption surfaces increased significantly.Whereas these change were not apparent in the vertebra.
Conclusion:It is concluded that L T4 caused secondary bone loss,in tibia,associated with increased bone turnover.There exists some heterogeneity in the different parts of skeleton in response to thyroid hormone. |
| KEYWORDS:Thyroid hormone Histomorphometry Osteoporosis |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 李红,高妍,马红,罗小云.大鼠不同部位骨骼对外源性甲状腺激素反应性的研究[J].中国骨伤,2002,15(9):534~536 |
| 英文格式: | LI Hong,GAO Yan,MA Hong.Responses in different skeletal sites of the rats to exogenous thyroid hormone[J].zhongguo gu shang / China J Orthop Trauma ,2002,15(9):534~536 |
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