| 活血化瘀中药对激素性股骨头坏死血浆TXB2与6-keto-PGF1α影响的实验研究 |
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Received:March 06, 2002
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| 作者 | Author | 单位 | Unit | E-Mail |
| 何伟 |
HE Wei |
广州中医药大学第一附属医院,广东广州510405 |
The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine Guangdong Guangzhou,510405 |
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| 徐传毅 |
XU Chuan yi |
广州中医药大学第一附属医院,广东广州510405 |
The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine Guangdong Guangzhou,510405 |
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| 樊粤光 |
FAN Yue guang |
广州中医药大学第一附属医院,广东广州510405 |
The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine Guangdong Guangzhou,510405 |
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| 方斌 |
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广州中医药大学第一附属医院,广东广州510405 |
The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine Guangdong Guangzhou,510405 |
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| 李雄 |
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广州中医药大学第一附属医院,广东广州510405 |
The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine Guangdong Guangzhou,510405 |
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| 王海彬 |
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广州中医药大学第一附属医院,广东广州510405 |
The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine Guangdong Guangzhou,510405 |
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| 刘少军 |
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广州中医药大学第一附属医院,广东广州510405 |
The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine Guangdong Guangzhou,510405 |
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| 袁浩 |
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广州中医药大学第一附属医院,广东广州510405 |
The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine Guangdong Guangzhou,510405 |
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| 期刊信息：《中国骨伤》2002年15卷，第9期，第531-533页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:广东省自然科学基金 990 367 |
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目的:探讨活血化瘀法在激素性股骨头坏死的治疗作用。
方法:用内毒素加激素注射造成兔股骨头坏死,测定其血浆TXB2和6ketoPGF1α的动态变化,以此作为血瘀证的观察指标。
结果:光镜观察示模型组股骨头骨小梁变细、空骨陷窝增加,成骨细胞数量减少,并出现TXB2与6ketoPGF1α比值失平衡,这些表现随着时间的推移逐渐加重;而用复方生脉成骨胶囊治疗能逆转股骨头坏死,保护血管内皮,恢复TXB2与6ketoPGF1α的平衡。
结论:激素性股骨头坏死与血瘀证之间有密切关系,用活血化瘀中药可防止股骨头坏死的发展。 |
| [关键词]:股骨头坏死 中医药现代化 内皮,血管 |
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| Experimental study of the influence of blood-circulation-activating traditional Chinese drugs on plasma TXB2 and 6-keto-PGF1α of glucocorticoid induced femoral head necrosis |
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Abstract:
Objective:To explore the therapeutic effects of blood circulation activating method on glucocorticoid induced femoral head necrosis (GANFH)
Methods:Rabbit models of GANFH were made by injecting endotoxin and methylprednisolone.Plasma TXB2 and 6 keto PGF1α were used as the objective indices for observing blood stasis.
Results:Light microscopy showed empty lacunae increased and numbers of osteoblasts and subchondral sinosoids decreased in model group;ratio of TXB2 and 6 keto PGF1α was out of balance.These changes were worsened with progress of the disease.Fufang Shengmai Chenggu Capsule could protect the vascular endothelial cells,recover the balance of TXB2 and 6 keto PGF1α ,which further reverse GANFH.
Conclusion:There is a closed relationship between GANFH and blood stasis.Blood circulation activating method may be beneficial for the reparative process of necrosis of the femoral head. |
| KEYWORDS:Femoral head necrosis Mordenization (TCM) Endothelium,vascular |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 何伟,徐传毅,樊粤光,方斌,李雄,王海彬,刘少军,袁浩.活血化瘀中药对激素性股骨头坏死血浆TXB2与6-keto-PGF1α影响的实验研究[J].中国骨伤,2002,15(9):531~533 |
| 英文格式: | HE Wei,XU Chuan yi,FAN Yue guang.Experimental study of the influence of blood-circulation-activating traditional Chinese drugs on plasma TXB2 and 6-keto-PGF1α of glucocorticoid induced femoral head necrosis[J].zhongguo gu shang / China J Orthop Trauma ,2002,15(9):531~533 |
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