| 补气通络方对大鼠坐骨神经轴突再生的影响 |
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Received:January 20, 2002
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| 作者 | Author | 单位 | Unit | E-Mail |
| 何振辉 |
HE Zhen hui |
广州中医药大学第一附属医院,广东广州510405 |
The First Affiliated Hospital of Guangzhou University of TCM Guangdong Guangzhou,510405 |
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| 姚珍松 |
YAO Zhen song |
广州中医药大学第一附属医院,广东广州510405 |
The First Affiliated Hospital of Guangzhou University of TCM Guangdong Guangzhou,510405 |
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| 劳镇国 |
LAO Zhen guo |
中山医科大学第一附属医院显微外科,广东广州 |
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| 晋大祥 |
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广州中医药大学第一附属医院,广东广州510405 |
The First Affiliated Hospital of Guangzhou University of TCM Guangdong Guangzhou,510405 |
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| 杨俊兴 |
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广州中医药大学第一附属医院,广东广州510405 |
The First Affiliated Hospital of Guangzhou University of TCM Guangdong Guangzhou,510405 |
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| 朱庆堂 |
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中山医科大学第一附属医院显微外科,广东广州 |
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| 朱苏滨 |
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广州中医药大学第一附属医院,广东广州510405 |
The First Affiliated Hospital of Guangzhou University of TCM Guangdong Guangzhou,510405 |
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| 期刊信息：《中国骨伤》2002年15卷，第8期，第468-470页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:广东省中医药管理局科研基金资助项目(编号97197) |
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目的:观察由黄芪、人参、当归、川芎、丹参等中药组成的补气通络方对促进大鼠损伤坐骨神经再生的效应,为临床用药提供依据。
方法:用48只雄性清洁级Wistar大鼠,行右坐骨神经切断后即刻神经外膜缝合法造模,后将大鼠随机分成4组:补气通络胶囊组、补气通络注射液组、维生素B1+B6组和空白对照组,每组12只。于造模术成功及处置后4周、8周和12周,从每组随机抽取4只大鼠取坐骨神经进行轴突计数,以神经轴突再生恢复率作为观测指标进行验证。
结果:补气通络胶囊组和补气通络注射液组大鼠坐骨神经轴突再生恢复率均优于维生素B1+B6组及空白对照组(P<0.05或P<0.01)。
结论:补气通络方有助于周围神经损伤后神经轴突的再生。 |
| [关键词]:引导组织再生 坐骨神经损伤 中药疗法 |
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| Study on effect of Buqi-Tongluo Formula on the axon regeneration of sciatic nerve in rats |
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Abstract:
Objective:To study the effect of Buqi Tongluo Formula (a compound TCM drug composed of Radix Astragali,Radix Ginseng,Radix Angelicae Sinensis,Rhizoma Chuanxiong,Radix Salviae Miltiorrhizae etc and supplied in the capsule and injection forms) on regeneration of axons of sciatic nerve of the rats in order to find out scientific basis for clinical application of the TCM formula
Methods:48 Wistar rat models were made by section of the right sciatic nerves of rats and immediately the epineurium were sutured.Then the rats with injured sciatic nerve were randomly divided into 4 groups:group Ⅰ were treated with Buqi Tongluo Capsule, group Ⅱ with Buqi Tongluo Injection ,group Ⅲ with Vitamin B1+B6 tablet,group Ⅳ with normal saline.At 4th,8th and 12 weeks after treatment,4 rats from each group had their sciatic Nerve Axon Counting(NAC) checked and compared with each other
Results:All rats which were treated with Buqi Tongluo Capsule or Buqi Tongluo Injection had a better recovery ratio of NAC than those which were treated with Vitamin B1+B6(P<0.05)or with normal saline(P<0.01).
Conclusion:Both Buqi Tongluo capsule and Buqi Tongluo injection could facilitate the regeneration of injured peripheral nerve. |
| KEYWORDS:Leading tissue regeneration Sciatic nerve injury Treatment with Chinese herbs |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 何振辉,姚珍松,劳镇国,晋大祥,杨俊兴,朱庆堂,朱苏滨.补气通络方对大鼠坐骨神经轴突再生的影响[J].中国骨伤,2002,15(8):468~470 |
| 英文格式: | HE Zhen hui,YAO Zhen song,LAO Zhen guo.Study on effect of Buqi-Tongluo Formula on the axon regeneration of sciatic nerve in rats[J].zhongguo gu shang / China J Orthop Trauma ,2002,15(8):468~470 |
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