| 家兔自体骨髓移植对骨痂中钙镁铜含量的影响 |
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Received:December 06, 2000
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| 期刊信息：《中国骨伤》2002年15卷，第2期，第82-83页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
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目的:探讨新骨的形成在骨髓移植术后2周尤为显著现象的机制。
方法:用34只家兔剥除双侧桡骨骨膜3cm,截除剥离骨膜后的桡骨中段1cm,1小时后去除骨缺损区血肿,从股骨大转子处抽取1ml骨髓,随机注入一侧桡骨缺损区作为实验侧,另一侧注入等量生理盐水作为对照侧,术后2、4、6、8周分批做放射学、组织学和骨痂中钙、镁、铜含量的检查。
结果:骨髓移植有肯定的成骨效果,术后2周实验侧骨痂中镁、铜及术后4周镁含量高于对照侧(P<0.01)。
结论:铜和镁在骨髓移植促进骨缺损愈合早期可能具有重要作用,移植术后的2周内补充铜和镁有可能提高骨髓移植的成骨能力。 |
| [关键词]:骨髓移植 骨生成 钙 镁 铜 |
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| Effect of autotransplantation of bone marrow on the contents of Ca,Cu and Mg in bony callus of rabbits |
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Abstract:
Objective: To explore the mechanism of the phenomenon that active osteogenesis took place at 2nd week after bone marrow transplantation
Methods: 34 rabbits were used in this study.Periosteum of bilateral radius of rabbits was stripped off for 3cm and the middle piece of the radius of 1cm was resected.At 1 hour after the operation,the hematoma of the bone defect area was evacualed.The bone marrow of 1ml was aspirated from greater trochanter of femur,and then injected into one side of radius defect,which was used as experimental group.Normal saline of the same amount was injected into the other side of radius and used as control group.At 2nd,4th,6th and 8th weeks,the samples were obtained for radiological and histological examinations and the contents of Ca,Mg and Cu in the callus were detected.
Results:The bone marrow transplantation was effective in promoting osteogenesis.The contents of Mg and Cu in callus at 2nd week after operation and the content of Mg at 4th week in experimental group were higher than that of control group(P<0.01).
Conclusion:Cu and Mg played important roles in osteogenesis at the early stage following bone marrow transplantation.If the two elements were supplemented at 2nd week after transplantation operation,the osteogenesis process might be promoted. |
| KEYWORDS:Bone marrow transplantation Osteogenesis Calcium Magnesium Copper |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 翟照,陈凤苞.家兔自体骨髓移植对骨痂中钙镁铜含量的影响[J].中国骨伤,2002,15(2):82~83 |
| 英文格式: | ZHAI Zhao,CHEN Feng bao..Effect of autotransplantation of bone marrow on the contents of Ca,Cu and Mg in bony callus of rabbits[J].zhongguo gu shang / China J Orthop Trauma ,2002,15(2):82~83 |
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