| 维生素D受体基因型与骨密度 |
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Received:September 30, 2000
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| 作者 | Author | 单位 | Unit | E-Mail |
| 陈训华 |
CHEN Xun-hua |
中国中医研究院骨伤科研究所,北京100700 |
The Orthopaedics and Traumatic Institute,Chinese Academy of TCM,Beijing,100700 |
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| 杨淑芹 |
YANG Shu-qin |
中国中医研究院骨伤科研究所,北京100700 |
The Orthopaedics and Traumatic Institute,Chinese Academy of TCM,Beijing,100700 |
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| 梁雅香 |
LIANG Ya-xiang |
中国中医研究院骨伤科研究所,北京100700 |
The Orthopaedics and Traumatic Institute,Chinese Academy of TCM,Beijing,100700 |
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| 张万强 |
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中国中医研究院骨伤科研究所,北京100700 |
The Orthopaedics and Traumatic Institute,Chinese Academy of TCM,Beijing,100700 |
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| 期刊信息：《中国骨伤》2001年14卷，第9期，第531-532页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:国家中医药管理局科研基金资助项目(972107) |
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目的：考察维生素D受体(VDR)基因多态性在我国汉族人群中的分布频率,分析VDR基因型与骨密度的关系。
方法：采用聚合酶链反应和限制性酶切技术检测100例绝经前健康妇女VDR基因多态性。应用双能X线骨密度仪检测受试者腰椎及髋部骨密度。
结果：VDR基因型分布频率为BB型4.0%,Bb型10.0%,bb型86.0%;而三种基因型受试者髋部及腰椎骨密度均表现出Bb>bb>BB,经F检验腰椎骨密度3基因型比较,P<0.05,具有显着差异。
结论：绝经前妇女VDR基因型分布频率与西方及国内的一些报道不尽相同,且骨密度显示出Bb>bb>BB,亦与国内外一些研究结果不同。 |
| [关键词]:骨密度 基因型 骨质疏松 腰椎 髋 |
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| The relationship between vitamin D receptor gene polymorphisms and bone mineral density |
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Abstract:
Objective:To study the frequency distribution of vitamin D receptor(VDR) gene polymorphisms in Chinese and to evaluate the relationship between VDR gene polymorphisms and bone mineral density(BMD)
Methods:VDR gene polymorphisms of 100 healthy pre-menopausal women was detected by using polymerase chain reaction(PCR) and restrictive analysis methods.The BMD values in lumbar vertebrae and hip of the women were measured by using dual energy X-ray absorptiometry(DEXA).
Results:The frequency distribution of VDR genotype was bb86.0%,Bb10.0% and BB4.0%.The BMD values in hip and lumbar vertebrae of the women with 3 type of gene were Bb>bb>BB(P<0.05).
Conclusion:In this study,the frequency distribution of VDR genotype in pre-memopausal women is sharply different from that of reports in western countries,as well as in Chinese.The BMD of Bb>bb>BB is also apart from other study results. |
| KEYWORDS:Bone density Genotype Osteoporosis Lumbar vertebrae Hip |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 陈训华,杨淑芹,梁雅香,张万强.维生素D受体基因型与骨密度[J].中国骨伤,2001,14(9):531~532 |
| 英文格式: | CHEN Xun-hua,YANG Shu-qin,LIANG Ya-xiang.The relationship between vitamin D receptor gene polymorphisms and bone mineral density[J].zhongguo gu shang / China J Orthop Trauma ,2001,14(9):531~532 |
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