| 黄芪预防术后硬膜外粘连的实验研究 |
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Received:November 24, 1999 Revised:March 02, 2000
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| 期刊信息：《中国骨伤》2001年14卷，第3期，第152-153页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:上海市卫生局课题(编号;95A2515) |
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目的;探讨黄芪预防术后硬膜外瘢痕粘连的效果。
方法;22只新西兰兔行L2和L5节段椎板切除术,切除部分黄韧带,暴露脂肪,去除硬膜外脂肪,分为两组;A组为黄芪组；B组为生理盐水组,分别在L2和L5椎板缺损区注入黄芪液和生理盐水,术后2、4、8周取材作光镜、透镜观察。
结果;黄芪组炎性细胞渗出较少,成纤维细胞较少,胶原纤维形成较少,硬膜外瘢痕无粘连,脊髓和神经根未见变性和脱髓鞘。生理盐水组硬膜外瘢痕粘连明显。
结论;黄芪无神经毒性作用,可以作为一种良好的材料用于预防术后硬膜外瘢痕粘连。 |
| [关键词]:中草药 术后并发症 组织细胞 |
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| An experimental study of prevent ive effects of Huangqi on postoperative peridural adhesion |
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Abstract:
Objective;To study the effects of Huangqi(Chinese herb)for prevention of peridural adhesio n after operation.
Methods;L2 and L5 laminectomy of 22 New Zealan d rabbits were performed in this experim ental study.Partial yellow ligament was sectioned and fat was exposed.Then the p eridural fat was sectioned.The 44 verteb ral lamina seyments were randomly divide d into two groups of a. Huangqi group an d b.Normal Saline(NS)group.The b group wa s control group.Huangqi liquid and NS we re separately injected into the defect p oints of L2 and L5 vertebral lamina of the two groups.The speciments were obta ined at 2nd,4th and 8th weeks after oper ation.Optical microscope and transmissio n electron microscope were used for the observation.
Results;There were many changes in group a;littl e migration of inflammation cells,small number of fibroblast and collagen,no adh esion of peridural scar,no degeneration and demyelination of spinal nerves.But i n group b,adhesion of peridural scar cou ld be seen clearly.
Conclusion;Huangqi has no nerve toxicity and it cou ld be used as a good medicine to prevent postoperative peridural adhesion. |
| KEYWORDS:Chinese herbal medicine Postoperative |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 沈权,侯筱魁,叶澄宇.黄芪预防术后硬膜外粘连的实验研究[J].中国骨伤,2001,14(3):152~153 |
| 英文格式: | Shen Quan,HOU Xiao kui,YE Cheng yu.An experimental study of prevent ive effects of Huangqi on postoperative peridural adhesion[J].zhongguo gu shang / China J Orthop Trauma ,2001,14(3):152~153 |
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