| 增龄及运动负荷对C57黑鼠关节软骨影响的组织病理学观察 |
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Received:September 21, 1998 Revised:March 08, 1999
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| 作者 | Author | 单位 | Unit | E-Mail |
| 汪青春 |
WANG Qing chun |
第一军医大学中医系骨伤科,广州510515 |
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| 石印玉 |
SHI Yin yu |
上海中医药大学附属曙光医院,上海200021 |
The Affiliated Shuguang Hospital,Shanghai University of TCM Shanghai,200021 |
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| 沈培芝 |
SHEN Pei zhi |
上海中医药大学附属曙光医院,上海200021 |
The Affiliated Shuguang Hospital,Shanghai University of TCM Shanghai,200021 |
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| 徐宇 |
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上海中医药大学附属曙光医院,上海200021 |
The Affiliated Shuguang Hospital,Shanghai University of TCM Shanghai,200021 |
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| 期刊信息：《中国骨伤》2000年13卷，第9期，第517-518页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:国家自然科学基金(39570880) |
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目的:观察年龄增长和运动负荷对骨关节的影响。
方法:将C57黑鼠42只随机分成自然增龄组和运动负荷组,自然增龄组小鼠分别于出生后6周、12周、20周、28周处死;负荷组小鼠分别于6周、14周、22周进行行走训练,于12周、20周、28周处死,观察两组动物关节软骨组织病理学的变化。
结果:负荷组的自发性骨关节炎的发生率及软骨退变严重度,均高于自然增龄组。
结论:C57黑鼠关节软骨随增龄自发OA样退变,运动负荷可加速软骨退变进程。 |
| [关键词]:骨关节炎 软骨 关节 病理学 |
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| Effect of aging and sports loading on articular cartilage of C57 black mice—an histopathological study |
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Abstract:
Objective:To observe the effects of aging and sports loading on the articular cartilage of C57 black mice.
Methods:42 C57 black mice were divided randomly into aging group and sports loading group.The mice of aging group were sacrified at 6th,12th,20th and 28th weeks.The mice of sports loading were trained walking at 6th,14th,22th weeks and were sacrified at 12th,20th and 28th weeks.The histopathological changes of knee articular cartilage in these two groups were compared under light microscope.
Results: The occurrence of osteoarthritis and the severity of cartilage degeneration in sports loading group were higher than those in aging group.
Conclusion:Spontaneous osteoarthritis developed spontaneouly in articular cartilage of C57 black mice by aging,and the process of cartilage degeneration was accelerated by sports loading. |
| KEYWORDS:Osteoarthritis Cartilage articular Pathology |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 汪青春,石印玉,沈培芝,徐宇.增龄及运动负荷对C57黑鼠关节软骨影响的组织病理学观察[J].中国骨伤,2000,13(9):517~518 |
| 英文格式: | WANG Qing chun,SHI Yin yu,SHEN Pei zhi.Effect of aging and sports loading on articular cartilage of C57 black mice—an histopathological study[J].zhongguo gu shang / China J Orthop Trauma ,2000,13(9):517~518 |
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