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肝细胞生长因子对膝关节软骨影响的临床意义

Hits: 1899 Download times: 1258 Received:November 17, 1999

作者	Author	单位	Unit	E-Mail
陈百成	CHEN Bai cheng	河北省骨科研究所,河北石家庄050051	Institute of Orthopaedics and Traumatology of Hebei Hebei Shijiazhuang,050051
张静	ZHANG Jing	河北省骨科研究所,河北石家庄050051	Institute of Orthopaedics and Traumatology of Hebei Hebei Shijiazhuang,050051
葛莉	GE Li	河北省骨科研究所,河北石家庄050051	Institute of Orthopaedics and Traumatology of Hebei Hebei Shijiazhuang,050051
苏莉		石家庄市第二医院,河北石家庄

期刊信息：《中国骨伤》2000年13卷，第7期，第401-403页

DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz

目的:研究前列腺素E₂(PGE₂)参与关节软骨退变的进程机理,以及肝细胞生长因子(HGF)对膝关节软骨损伤修复的作用机理。

方法:对符合临床诊断标准的30个膝关节,分别给予膝关节腔注射肝细胞生长因子,每天1次,每次2ml,观察PGE₂、尿中Ⅰ型胶原(crosslaps)、碱性磷酸酶(AKP)以及临床症状的改善程度,并做了给药6周后与给药前的对比研究。

结果:给药6周后crosslaps和PGE₂与给药前比较均明显降低(P<0.01,P<0.001).给药6周后临床症状均有不同程度的改善。

结论:PGE₂参与了软骨损伤的某些阶段,肝细胞生长因子对膝关节软骨的修复有促进作用。

[关键词]:软骨关节膝关节前列腺素E类

Clinical effect of hepatocyte growth factor on articular cartilage of the knee

Abstract:

Objective:To explore the mechanism of prostaglandins E₂(PGE₂) affecting cartilage degeneration stage and the effect of hepatocyte growth factor(HGF) on the repair of injured articular cartilage of the knee.

Methods:HGF(2 ml,once daily)were injected into 30 knee joints which met to clinical diagnostic standard of osteoarthritis.The PGE₂,crosslaps,AKP and the improvement of clinical symptom were investigated.

Results:After 6 weeks,the contents of PGE₂ and crosslaps decreased notably compared with that of before the treatment (P<0 01,P<0 001),meanwhile the clinical symptoms were also improved to different extents.

Conclusion:PGE₂ had involvements in certain stages of articular cartilage damage.HGF had a promotion effect on the repair process of cartilage.

KEYWORDS:Cartilage articular Knee joint Prostaglandins E

引用本文，请按以下格式著录参考文献：

中文格式:	陈百成,张静,葛莉,苏莉.肝细胞生长因子对膝关节软骨影响的临床意义[J].中国骨伤,2000,13(7):401~403
英文格式:	CHEN Bai cheng,ZHANG Jing,GE Li.Clinical effect of hepatocyte growth factor on articular cartilage of the knee[J].zhongguo gu shang / China J Orthop Trauma ,2000,13(7):401~403

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