| 大鼠后肢短暂缺血后胫骨骨膜变化的组织学观察 |
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Received:January 11, 1999 Revised:April 27, 1999
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| 期刊信息：《中国骨伤》2000年13卷，第7期，第393-395页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
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目的:探讨缺血对骨外膜的影响。
方法:于SD大鼠(n=50)右后肢大腿中段经止血带结扎缺血15小时后,分别饲养3天(Ⅰ组)和10天(Ⅱ组),以及缺血45小时后分别饲养3天(Ⅲ组)和10天(Ⅳ组),经切片观察胫骨骨膜组织病理学变化。
结果:光镜观察发现Ⅰ、Ⅱ组右侧胫骨骨外膜细胞(PCRT)无明显变化;Ⅲ组PCRT明显增生肥大,伴有大量编织骨形成;Ⅳ组PCRT增生明显减弱,无新的编织骨形成,骨髓内小血管周围可见骨化灶。Ⅲ、Ⅳ组PCRT和髓内变化情况与骨折愈合过程中外骨痂和内骨痂的形成相类似。
结论:大鼠后肢严重缺血可引起胫骨骨外膜增生及成骨,但作用是短暂的。骨折局部的严重缺血可能是起动骨折愈合过程的一个重要因素。 |
| [关键词]:骨膜 缺血 骨折愈合 组织病理学 |
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| Histopathological observation of tibia periosteum of rats after transient posterior limb ischemia |
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Abstract:
Objective:To explore the effect of ischemia on periosteum
Methods:Ischemia SD rat models (n=50)were established by application of tourniquet on middle third of right posterior limb After 1 5 hours of ischemia the rats were raised 3(group Ⅰ)and 10 days (group Ⅱ)respectively,and after 4 5 hours of ischemia the rats were also raised 3(group Ⅲ) and 10 days (group Ⅳ)respectively [HT5”H]
Results:The periosteal cells of right tibia (PCRT)had no obvious changes in group Ⅰ and Ⅱ Hyperplastic and hypertrophic PCRT could be seen notably in group Ⅲ and a large amount of woven bones were formed In group Ⅳ,hyperplasia of PCRT was much less than that in group Ⅲ and there was no new woven bone formed; meanwhile the circumvascular ossification was found in bone marrow The change of PCRT and bone marrow in group Ⅲ and Ⅳ were similar to initial formation of external and medullar callus during fracture healing
Conclusion: Severe ischemia of hind limb of rats can induce hyperplasia and hypertrophy of periosteum of the tibia;but the effect is transient It suggests that severe ischemia in the region of fracture may be an important factor in initiating the process of fracture healing. |
| KEYWORDS:Periosteum Ischemia Fracture healing Histopathology |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 程迅生,周维江,张勇,李嘉寿.大鼠后肢短暂缺血后胫骨骨膜变化的组织学观察[J].中国骨伤,2000,13(7):393~395 |
| 英文格式: | CHENG Xun sheng,ZHOU Wei jiang,ZHANG Yong.Histopathological observation of tibia periosteum of rats after transient posterior limb ischemia[J].zhongguo gu shang / China J Orthop Trauma ,2000,13(7):393~395 |
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