| 类风湿关节炎及骨关节炎血清和滑液中一氧化氮的测定 |
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Received:January 15, 1998 Revised:May 05, 1998
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| 期刊信息：《中国骨伤》2000年13卷，第5期，第276-277页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
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目的:研究一氧化氮(NO)在类风湿性关节炎(RA)及骨关节炎(OA)病变中的作用。
方法:采用亚硝酸盐间接法测定了40例RA、20例OA患者血清及滑液NO的含量变化,并与年龄相匹配的健康人相比较。
结果:RA患者血清及滑液NO的浓度呈正相关(r=0.417,P<0.05).RA和OA患者血清NO浓度均低于滑液中的,但显着高于正常对照组血清NO浓度;RA患者滑液NO浓度高于血清中,且明显高于OA组滑液NO浓度。
结论:NO在RA和OA患者骨关节中可能主要由滑膜产生;NO可能参与了类风湿性关节炎病变过程,且在其中起一定损害作用。 |
| [关键词]:关节炎,类风湿 骨关节炎 一氧化氮 |
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| Determination of Nitrogen Mono oxide in Synovia and Blood Serum of Patients with Rheumatoid Arthritis and Osteoarthritis |
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Abstract:
Objective:To evaluate the role of nitrous oxide (NO) in the pathogenesis of rheumatoid arthritis(RA)and osteoarthritis(OA)
Methods:The change of NO content in 40 cases of RA and 24 cases of OA of the hip were determined by nitrite indirect method The results were compared with the data obtained from specimens of healthy persons(blood serum specimens)
Results:In patients with RA,NO concentration in blood serum was positively correlated to that in the synovia(r=0 417,P<0.05) In patients with RA and OA,NO concentration in blood serum was lower than that in synovia,but significantly higher than that in control group NO concentration in synovia in patients with RA was obviously higher than that in patients with OA
Conclusions:In patients with RA and OA,intra articular NO is mainly synthesised by the synovium.The increased NO concentration in blood serum sugg ested its involvement in the pat hogensis of RA. |
| KEYWORDS:Arthritis rheumatoid Osteoarthritis Nitric oxide |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 高培国,武永刚,王坤正,李旭东.类风湿关节炎及骨关节炎血清和滑液中一氧化氮的测定[J].中国骨伤,2000,13(5):276~277 |
| 英文格式: | GAO Pei guo,WU Yong gang,WANG Kun zheng.Determination of Nitrogen Mono oxide in Synovia and Blood Serum of Patients with Rheumatoid Arthritis and Osteoarthritis[J].zhongguo gu shang / China J Orthop Trauma ,2000,13(5):276~277 |
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