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实验性动物股骨头坏死模型的制备及其病理生理机制

Hits: 2435 Download times: 1371 Received:August 21, 1998

作者	Author	单位	Unit	E-Mail
杨明亮	YANG Ming liang	中国康复研究中心,北京100077	Chinese Rehabilitation Research Centre Beijing,100077
罗先正	LUO Xian zheng	北京友谊医院,北京
王正明	WANG Zheng ming	北京友谊医院,北京

期刊信息：《中国骨伤》2000年13卷，第4期，第207-208页

DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz

目的：探讨股骨头坏死的病理演进机制及预后。

方法：采用12N盐酸、12N氢氧化钠依次注入家兔股骨头内灭活骨细胞、骨髓组织及破坏股骨头内的微循环。

结果：在短时期内复制出进展期的股骨头坏死模型,6周左右即可出现典型的骨坏死病理。

结论：病因、骨吸收及骨有效重建的平衡状态、生物力学三方面因素综合作用,决定股骨头坏死的病理演进及预后。股骨头坏死的有效修复不仅仅是坏死的骨小梁重建,还应包括遭受损害的微循环及骨髓功能的恢复。

[关键词]:股骨头坏死病理过程组织学

Pathophysiological Mechanism of Ischemic Necrosis of the Femoral Head on experimental study

Abstract:

Objective:To explore the mechanism of pathological process of ischemic necrosis of femoral head(INFH) and its prognosis in animal models

Methods:12N HCl and 12N NaOH were injected into femoral heads of rabbits to kill bone cells,bone marrow and to destroy microcirculation

Results:INFH model in progressive stage was duplicated in short period and the typical pathological changes appeared after 6 weeks

Conclusion s:The development and prognosis of INFH depend on three factors,i e pathogenic agents,balance of bone absorption and bone reconstruction,effect of biomechanics The effective repair of INFH includes not only the reconstruction of trabecular network but also the restoration of the function of microcirculation and bone marrow

KEYWORDS:Femur head necrosis Pathologic processes Histology

引用本文，请按以下格式著录参考文献：

中文格式:	杨明亮,罗先正,王正明.实验性动物股骨头坏死模型的制备及其病理生理机制[J].中国骨伤,2000,13(4):207~208
英文格式:	YANG Ming liang,LUO Xian zheng,WANG Zheng ming.Pathophysiological Mechanism of Ischemic Necrosis of the Femoral Head on experimental study[J].zhongguo gu shang / China J Orthop Trauma ,2000,13(4):207~208

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