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骨疏康对卵巢切除大鼠骨质量及基因表达的影响

Hits: 2167 Download times: 1457 Received:April 01, 1999 Revised:August 07, 1999

作者	Author	单位	Unit	E-Mail
薛延	XUE Yan	北京创伤骨科研究所骨与关节病研究中心,北京100035	Bone & Joint Diseases Center Beijing Institute of Traumatology & Orthopaedics Beijing 100035
包方	BAO Fang	北京创伤骨科研究所骨与关节病研究中心,北京100035	Bone & Joint Diseases Center Beijing Institute of Traumatology & Orthopaedics Beijing 100035
李东	LI Dong	北京创伤骨科研究所骨与关节病研究中心,北京100035	Bone & Joint Diseases Center Beijing Institute of Traumatology & Orthopaedics Beijing 100035
刚丕寰		辽宁中医研究院,辽宁沈阳
蒋淑媛		辽宁中医研究院,辽宁沈阳
黄公怡		北京医院,北京

期刊信息：《中国骨伤》2000年13卷，第3期，第141-143页

DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz

基金项目:国家科委九五攻关资助课题(项目编号:96-906-05-04)

目的:为进一步探讨骨疏康防治骨质疏松的作用机理。

方法:将27只3月龄Wistar雌性大鼠随机分为三组:假手术组(Sham)、卵巢切除组(OVX)、骨疏康组(GSK).给药后12周同时处死。取大鼠血、尿检测骨代谢生化指标,取股骨或腰椎测量骨密度、骨形态计量学参数、骨生物力学参数,取股骨和胫骨,测定骨粘连蛋白(ON)mRNA表达。

结果:与OVX组相比,GSK组股骨及L4骨密度明显增高,生物力学参数也有增加。GSK有抑制骨吸收作用。

结论:GSK增加骨量和骨强度的作用。

[关键词]:去卵巢生物力学骨形态计量学中草药骨质疏松

Eeffect of Gushukang on bone quality and gene expression of osteonectin in ovariectomized rats.

Abstract:

Objective:To investigate the mechanisms of prevention and treatment of Gushukang on osteoporosis.

Methods:Ovariectomized(OVX)female Wistar rats(3 months old)were divided into three groups randomly:sham group.OVX group and GSK group.Biochemical markers,bone mineral density(BMD),bone histomorphometry,bone biomechanical properties and the expression of osteonectin(ON)mRNA of femur and tibia were measured at the end of the experiment.

Results:Compared with OVX rats,GSK significantly increased BMD of femur and L 4,also increased the mechanical properties of OVX rats.GSK inhibited bone resorption.

Conclusion:GSK increased bone mass and bone strength.

KEYWORDS:Ovariectomized Biomechanics Bone histomorphometry Chinese herbal drugs Osteoporosis

引用本文，请按以下格式著录参考文献：

中文格式:	薛延,包方,李东,刚丕寰,蒋淑媛,黄公怡.骨疏康对卵巢切除大鼠骨质量及基因表达的影响[J].中国骨伤,2000,13(3):141~143
英文格式:	XUE Yan,BAO Fang,LI Dong.Eeffect of Gushukang on bone quality and gene expression of osteonectin in ovariectomized rats.[J].zhongguo gu shang / China J Orthop Trauma ,2000,13(3):141~143

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