| 家兔膝关节创伤性骨化性肌炎动物模型的建立 |
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Received:September 21, 1998 Revised:June 22, 1999
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| 作者 | Author | 单位 | Unit | E-Mail |
| 邓柏杰 |
DENG Bai jie |
佛山市中医院,广东佛山528000 |
Foshan Hospital of Traditional Chinese Medicine Guangdong Foshan,528000 |
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| 陈渭良 |
CHEN Wei liang |
佛山市中医院,广东佛山528000 |
Foshan Hospital of Traditional Chinese Medicine Guangdong Foshan,528000 |
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| 张继平 |
ZHANG Ji ping |
佛山市中医院,广东佛山528000 |
Foshan Hospital of Traditional Chinese Medicine Guangdong Foshan,528000 |
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| 何秋月 |
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佛山市中医院,广东佛山528000 |
Foshan Hospital of Traditional Chinese Medicine Guangdong Foshan,528000 |
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| 香卫红 |
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佛山市中医院,广东佛山528000 |
Foshan Hospital of Traditional Chinese Medicine Guangdong Foshan,528000 |
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| 谭光明 |
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佛山市中医院,广东佛山528000 |
Foshan Hospital of Traditional Chinese Medicine Guangdong Foshan,528000 |
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| 期刊信息：《中国骨伤》2000年13卷，第2期，第80-82页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:广东省中医药管理局科研基金(编号:粤90-92 ) |
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目的:建立家兔膝关节创伤性骨化性肌炎动物模型。
方法:用新西兰白色家兔10只,进行强力被动扭转、暴力按摩,造成膝关节及周围软组织损伤,然后固定膝关节于伸直位。从第1周开始每周按摩6天,第5周开始改为隔天按摩一次,并观察皮温、肿胀度、局部体征、局部骨化情况。至第9周进行病理、组织学检查。
结果:模型局部肿胀明显；皮温升高；患肢关节强直,伸屈功能明显障碍,最后关节僵硬,膝关节周围肌群可触摸到肌肉硬块；X线片示全部出现明显骨化影；病理检查示肌束间组织广泛水肿,伴有轻度炎症反应,血管和成纤维细胞增生,肌束间纤维组织增生明显,并形成类骨组织和类软骨组织,局部出现较明显的异位骨化。
结论:该动物模型与临床创伤性骨化性肌炎表现和国外文献一致,说明模型复制成功。 |
| [关键词]:骨化性肌炎 实验研究 动物模型 |
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| Setting up of the Animal Model of Traumatic Myositis Ossificans in Rabbits' Knee Joint |
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Abstract:
Objective:To set up the animal model of the traumatic myositis ossificans around the knee joints of the rabbits
Methods:Ten white New Zealand rabbits were strongly torn and violently massaged to result in soft tissue injuries around the knee joints Then the joints were fixed in extension position Local swelling,skin temperature,degree of ossification and local signs were observed after massaging once daily during the first week to the fourth week and alternative days from the fifth week on Pathological examination had been done in the ninth week
Results: It was showed that the local swelling was severe,the skin temperature was high,the wounded limb joint was stiff and the function of extension flexion was impaired obviously One can feel the ossified muscles around the stiff joint Meanwhile,ossification could be seen clearly in X ray film The extensive edema with inflammatory reaction,hyperplastic vessel,fibroblast and fibrous tissue,osteoid and chondroid tissue,obvious ossification could be seen in pathological examination
Conclusion:The model can mimic the clinical syndromes of traumatic myositis ossificans;the method is in agreement with that reported in domestic as well as in foreign literatures |
| KEYWORDS:Traumatic myositis ossificans Experimental study Animal model |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 邓柏杰,陈渭良,张继平,何秋月,香卫红,谭光明.家兔膝关节创伤性骨化性肌炎动物模型的建立[J].中国骨伤,2000,13(2):80~82 |
| 英文格式: | DENG Bai jie,CHEN Wei liang,ZHANG Ji ping.Setting up of the Animal Model of Traumatic Myositis Ossificans in Rabbits' Knee Joint[J].zhongguo gu shang / China J Orthop Trauma ,2000,13(2):80~82 |
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