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大鼠脊髓受压后的病理学变化

Hits: 2098 Download times: 1220 Received:October 21, 1997 Revised:May 10, 1998

作者	Author	单位	Unit	E-Mail
郑清波	Zheng Qingbo	上海医科大学中山医院,上海200032	Zhongshan Hospital,Shanghai Medical University 200032
施杞	Shi Qi	上海中医药大学,上海
姜立本	Jiang Liben	上海医科大学中山医院,上海200032	Zhongshan Hospital,Shanghai Medical University 200032

期刊信息：《中国骨伤》1999年12卷，第5期，第22-24页

DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz

目的:观察脊髓受压后的病理学变化。

方法:通过注射106Walker256癌细胞液到大鼠T₁₃椎体前,建立脊髓硬膜外压迫实验模型。大约16天左右所有动物产生瘫痪,快速切取受压处的脊髓组织作透射电镜观察。

结果:电镜发现脊髓白质细胞间隙扩大,含有外渗的血液细胞,并见髓鞘退变。

结论:研究提示脊髓受压后的水肿在神经功能障碍的形成中起着重要作用。

[关键词]:脊髓压迫病理学

Pathological Changes of Spinal Cord after Compression in the Rat

Abstract:

Objective:To study pathological changes of spinal cord after compression.

Methods: Extradural spinal cord compression model was induced in Wistar rats by percutaneous inoculation of Walker 256 carcinoma cell suspension (10⁶ cells per rat) anterior to T₁₃ vertebral body.When paraplegia was occurred about 16 days after tumor inoculation,the bolck of compressed spinal cord was taken out for the examination with transmission electron microscope.

Results: The enlarged interstitial space,degenerated myelin sheath,and extravasated blood cells were found in white matter of the compressed spinal cord.

Conclusion: Edema in compressed spinal cord plays an important role in the occurrence of neural dysfunction.

KEYWORDS:Spinal cord Compression Pathology

引用本文，请按以下格式著录参考文献：

中文格式:	郑清波,施杞,姜立本.大鼠脊髓受压后的病理学变化[J].中国骨伤,1999,12(5):22~24
英文格式:	Zheng Qingbo,Shi Qi,Jiang Liben.Pathological Changes of Spinal Cord after Compression in the Rat[J].zhongguo gu shang / China J Orthop Trauma ,1999,12(5):22~24

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