| 骨质疏松症与退行性骨关节病相关性实验研究——模型鼠血清碱性磷酸酶与酸性磷酸酶含量测定 |
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Received:January 30, 1999
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| 期刊信息：《中国骨伤》1999年12卷，第4期，第14-17页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
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目的：观察各组模型动物体内碱性磷酸酶（ALP）与酸性磷酸酶（TRAP）水平变化，探讨骨质疏松症与退行性骨关节病的相互关系。
方法：70只初生雌性大白鼠分为4组（正常对照组A、去卵巢组B、双后肢组C、去卵巢双后肢组D）.造模后，于生长的不同阶段取血，用生物试剂盒测定。
结果：ALP水平在各时间段B、C、D组均显着高于A组，B、C组均显着低于D组；TRAP水平在各时间段B组均显着高于A、C、D组，C组低于A组。
结论：负重加大可刺激成骨细胞活性，抑制破骨细胞活性，促进骨形成；雌激素减少可同时增强成骨细胞与破骨细胞活性，只是破骨作用的增强要高于成骨的增强，最终表现为骨丢失。 |
| [关键词]:骨质疏松 骨关节病 雌激素 负重 |
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| Experimental Study on the Relationship between Osteoporosis and Osteoarthrosis The Test of Serum ALP and TRAP Content in Model Rats |
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Abstract:
Objective: To investigate the changes of the level of alkaline phosphatase (ALP) and acid phosphatase (TRAP) in various groups of model rats and to explore the relationship between osteoporosis and osteoarthrosis.
Methods: 70 new born female Wistar rats were divided into four groups:group A (the control),group B (the ovariectomized),group C (the bipedal group by amputation of the forelimbs),and group D (the ovariectomized bipedal group).At different times of postnatal growth,the blood samples were taken out to test the content of serum ALP and TRAP.
Results:The ALP level of group B, C and D was significantly higher than that of group A,and that of group B and C was significantly lower than that of group D.The TRAP level of group B was significantly higher than that of group A, C and D,and that of group C was lower than that of group A.
Conclusion: Weight bearing can stimulate the activity of osteoblost and inhibit the activity of osteoclast,so that it can promote the bone formation.The deficiency of estrogen may increase the activity of both osteoblast and osteoclast,but the increase of osteoclast activity is higher than that of osteoblast,so that the final manifestation is the bone loss. |
| KEYWORDS:Osteoporosis Osteoarthrosis Estrogen Weight bearing |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 魏泉洁,蒋位庄,张晓铀.骨质疏松症与退行性骨关节病相关性实验研究——模型鼠血清碱性磷酸酶与酸性磷酸酶含量测定[J].中国骨伤,1999,12(4):14~17 |
| 英文格式: | .Experimental Study on the Relationship between Osteoporosis and Osteoarthrosis The Test of Serum ALP and TRAP Content in Model Rats[J].zhongguo gu shang / China J Orthop Trauma ,1999,12(4):14~17 |
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