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硒对家兔实验性骨折愈合过程影响的病理研究

Hits: 2099 Download times: 1625 Received:April 21, 1997 Revised:April 13, 1998

作者	Author	单位	Unit	E-Mail
卫建平	Wei Jianping	山西医科大学第二临床医院,太原030001	The Second Teaching Hospital of Shanxi Medical University Taiyuan 030001
芦汉生	Lu Hansheng	山西医科大学第二临床医院,太原030001	The Second Teaching Hospital of Shanxi Medical University Taiyuan 030001
杜爱平	Du Aiping	山西医科大学第二临床医院,太原030001	The Second Teaching Hospital of Shanxi Medical University Taiyuan 030001
薛华新	Xue Huaxin	山西医科大学第二临床医院,太原030001	The Second Teaching Hospital of Shanxi Medical University Taiyuan 030001

期刊信息：《中国骨伤》1999年12卷，第2期，第17-19页

DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz

目的：研究硒对骨折愈合的影响。

方法：应用40只家兔做成双侧肱骨中段实验性骨折，随机分为2组：对照组饲常规饲料；实验组每日加饲微量元素硒0.6mg.术后2、3、4、5周取材，进行骨痂横截面积测量，光镜及电镜观察。

结果：实验组2～4周骨痂内的软骨细胞、成骨细胞等及基质的变化较对照组出现早，且功能活跃。

结论：饲料中加硒可促进兔骨折愈合, 这可能与硒刺激软骨细胞的蛋白合成有关。

[关键词]:骨折愈合微量元素硒软骨细胞

Pathological Study on the Effect of Selenium in the Healing Process of Experimental Fracture in Rabbits

Abstract:

Objective:To study the effect of trace element,selenium(Se)in the healing process of fracture.

Method:s Forty rabbits had been made experimental fractures at the middle shaft of the humerus bilaterally and divided into two groups randomly:the control group,fed with common forage;the experimental group,fed with Se(0.6mg/day)additionally.The specimens were taken out 2,3,4,and 5 weeks after operation,cross sections of the calluses were made to measure the area of the callus and to observe the structures with light and electron microscope.

Results: At 2 and 4 weeks,the appearance of chondrocyte and osteoblast and the changes of matrix in the callus of experimental group were much more earlier and the function of chondrocyte and osteoblast was more active.

Conclusion: Se added in forage could stimulate the synthesis of protein in chondrocyte to promote the healing of rabbits fracture.

KEYWORDS:Fracture union Trace element Selenium Chondrocyte

引用本文，请按以下格式著录参考文献：

中文格式:	卫建平,芦汉生,杜爱平,薛华新.硒对家兔实验性骨折愈合过程影响的病理研究[J].中国骨伤,1999,12(2):17~19
英文格式:	Wei Jianping,Lu Hansheng,Du Aiping,Xue Huaxin.Pathological Study on the Effect of Selenium in the Healing Process of Experimental Fracture in Rabbits[J].zhongguo gu shang / China J Orthop Trauma ,1999,12(2):17~19

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