| 股骨头I号方药作用机理的实验研究 |
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Received:February 10, 1996 Revised:April 10, 1998
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| 作者 | Author | 单位 | Unit | E-Mail |
| 范明 |
Fan Ming |
中国中医研究院骨伤科研究所,100700 |
Institute of Orthopaedics and Traumatology,China Academy of Traditional Chinese Medicine Beijing 100700 |
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| 程爱华 |
Cheng Aihua |
中国中医研究院骨伤科研究所,100700 |
Institute of Orthopaedics and Traumatology,China Academy of Traditional Chinese Medicine Beijing 100700 |
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| 王晶 |
Wang Jing |
中国中医研究院骨伤科研究所,100700 |
Institute of Orthopaedics and Traumatology,China Academy of Traditional Chinese Medicine Beijing 100700 |
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| 龚翠红 |
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中国中医研究院骨伤科研究所,100700 |
Institute of Orthopaedics and Traumatology,China Academy of Traditional Chinese Medicine Beijing 100700 |
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| 邢美荣 |
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中国中医研究院骨伤科研究所,100700 |
Institute of Orthopaedics and Traumatology,China Academy of Traditional Chinese Medicine Beijing 100700 |
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| 陈训华 |
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中国中医研究院骨伤科研究所,100700 |
Institute of Orthopaedics and Traumatology,China Academy of Traditional Chinese Medicine Beijing 100700 |
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| 杨淑芹 |
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中国中医研究院骨伤科研究所,100700 |
Institute of Orthopaedics and Traumatology,China Academy of Traditional Chinese Medicine Beijing 100700 |
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| 卜海滨 |
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中国中医研究院骨伤科研究所,100700 |
Institute of Orthopaedics and Traumatology,China Academy of Traditional Chinese Medicine Beijing 100700 |
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| 常超英 |
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中国中医研究院骨伤科研究所,100700 |
Institute of Orthopaedics and Traumatology,China Academy of Traditional Chinese Medicine Beijing 100700 |
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| 刘恩 |
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中国中医研究院骨伤科研究所,100700 |
Institute of Orthopaedics and Traumatology,China Academy of Traditional Chinese Medicine Beijing 100700 |
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| 韩凤岳 |
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中国中医研究院骨伤科研究所,100700 |
Institute of Orthopaedics and Traumatology,China Academy of Traditional Chinese Medicine Beijing 100700 |
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| 期刊信息：《中国骨伤》1999年12卷，第1期，第17-20页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
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目的：研究对股骨头早期坏死有疗效的中药汤剂股骨头I号方药（以下简称I号药）的作用机理。
方法：用昆明小白鼠进行扭体试验、抗巴豆油致炎试验和游泳能力试验，检测I号药的镇痛、消炎和增强体能的效应。用醋酸氢化考地松造成家兔股骨头早期坏死的模型，分别用I号药、马氏骨丸和生理盐水进行1个月的治疗。为了评定I号药的疗效和机理，在造模前、造模后和治疗后，分别进行3次血清GOT、TG和髋区的骨密度测定和病理组织学检查。
结果和结论： 1号药有良好的镇痛、抗炎消肿和提高体能的效应；有降低GOT、TG和提高骨密度的作用；I号药可以逆转激素诱发的股骨头骨质和骨髓早期的破坏、吸收和坏死等病理组织学变化，使其恢复近于正常股骨头的结构。 |
| [关键词]:股骨头坏死 中医药治疗 病理学 |
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| The Experimental Research on the Mechanism in Effect of Recipe Femoral Head No.I |
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Abstract:
Objective:To study the mechanism of therapeutic effect of Chinese traditional decoction,Femoral Head No.I (FHI) at the early stage of femoral head necrosis.
Methods:Kunming mice were applied to the body turning test,anti croton oil induced inflammation test,and swimming ability test,for examining the effectiveness of FHI on analgesia,anti inflammation,and enhancement of physical ability.Rabbits’ models of femoral head necrosis at early stage induced with hydrocortisone acetate,were treated with FHI,Ma’s Gu Wan,and normal saline for one month,respectively.In order to evaluate the therapeutic effect and its mechanism of FNI,before and after modeling and after treating,the content of serum GOT and TG,the bone density of hip region,and the pathohistology of femoral head were examined.
Results: and
Conclusion: There is good effect of FHI on analgesia,anti inflammation,repercussion,and elevation of physical ability.It plays a role in decreasing serum GOT and TG and in increasing bone density.FHI can reverse hydrocortisone induced pathohistological changes,such as the destruction,resorption and necrosis of bone mass and bone marrow at early stage of femoral head necrosis,thus recovering the structure of femoral head to approximately normal level. |
| KEYWORDS:Femoral head necrosis Treatment with Chinese drugs Pathology |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 范明,程爱华,王晶,龚翠红,邢美荣,陈训华,杨淑芹,卜海滨,常超英,刘恩,韩凤岳.股骨头I号方药作用机理的实验研究[J].中国骨伤,1999,12(1):17~20 |
| 英文格式: | Fan Ming,Cheng Aihua,Wang Jing.The Experimental Research on the Mechanism in Effect of Recipe Femoral Head No.I[J].zhongguo gu shang / China J Orthop Trauma ,1999,12(1):17~20 |
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