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骨愈灵对骨质疏松症大鼠骨代谢影响的研究

Hits: 2067 Download times: 1159 Received:April 22, 1995 Revised:December 20, 1997

作者	Author	单位	Unit	E-Mail
丁桂芝	Ding Guizhi	武汉同济医科大学协和医院,430022	Xiehe Hospital, Tongji Medical University Wuhan 430022
周勇	Zhou Yong	武汉市长江医院
李榕	Li Rong	武汉同济医科大学协和医院,430022	Xiehe Hospital, Tongji Medical University Wuhan 430022
曾天舒	Zeng Tianshu	武汉同济医科大学协和医院,430022	Xiehe Hospital, Tongji Medical University Wuhan 430022

期刊信息：《中国骨伤》1998年11卷，第5期，第12-14页

DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz

基金项目:国家中医药管理局重点课题基金（92B072）

目的:探讨骨愈灵对骨质疏松症大鼠骨代谢的影响。

方法:采用维甲酸灌饲造成大鼠骨质疏松症模型,使用骨愈灵胶囊进行治疗。

结果:使用骨愈灵治疗的大鼠胫骨骨小梁和股骨形态计量学各项指标均比模型组有显着性改善(P<0.05～0.01);治疗组大鼠股骨生物力学各检测参数亦显着好于模型组(P<0.05～0.001).

结论:骨愈灵治疗可改善维甲酸所致骨质疏松症大鼠的骨质丢失状态,提高骨的机械性能,避免或减少骨折的发生。

[关键词]:骨愈灵胶囊骨质疏松症骨密度骨生物力

Study of the Effect of Gu Yu Ling on Bone Metabolism in Osteoporotic Rat

Abstract:

Aim To inquire into the effect of Chinese drug Gu Yu Ling (GYL) on bone metabolism in osteoporotic rat.

Methods Osteoporotic rats were remodeled with retinoic acid and divided into the modeled group and the GYL treated group.

Results The bone histomorphometrologic indexes of tibia and femur in GYL treated group were significantly improved as compared with those in modeled group and the biomechanical parameters of the femur in GYL treated group were better than those in modeled group.

Conclusion The GYL therapy can improve the loss of bone substance and the biomechanical property of bone in osteoporotic rats.

KEYWORDS:Chinese drug Gu Yu Ling Capsule Osteoporosis Bone density biomechanics

引用本文，请按以下格式著录参考文献：

中文格式:	丁桂芝,周勇,李榕,曾天舒.骨愈灵对骨质疏松症大鼠骨代谢影响的研究[J].中国骨伤,1998,11(5):12~14
英文格式:	Ding Guizhi,Zhou Yong,Li Rong,Zeng Tianshu.Study of the Effect of Gu Yu Ling on Bone Metabolism in Osteoporotic Rat[J].zhongguo gu shang / China J Orthop Trauma ,1998,11(5):12~14

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