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脊髓Ⅱ号治疗大鼠脊髓损伤的病理组织学研究

Hits: 1663 Download times: 1144 Received:September 21, 1997 Revised:March 01, 1998

作者	Author	单位	Unit	E-Mail
韩凤岳	Han Fengyue	中国中医研究院骨伤科研究所,北京100700	Institute of Orthopaedics and Traumatology, China Academy of Traditional Chinese Medicine Beijing 100700
张凤绥	Zhang Fengsui	煤炭部总医院
刘卫东	Liu Weidong	中国中医研究院骨伤科研究所,北京100700	Institute of Orthopaedics and Traumatology, China Academy of Traditional Chinese Medicine Beijing 100700

期刊信息：《中国骨伤》1998年11卷，第5期，第9-11页

DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz

目的: 观察脊髓Ⅱ号方剂对大鼠损伤脊髓神经元修复再生的影响。

方法: 制作18只T₁₂ 右半横断的Wistar大鼠模型,随机分为3组:脊髓Ⅱ号组、氢化可的松组、空白对照组,分别给予脊髓Ⅱ号药液、激素、生理盐水。4周后取材,作神经病理组织学检查。

结果:脊髓Ⅱ号方剂具有明显疗效,可以缩小损伤区域,抑制继发损伤,促进神经元胞体及神经纤维的修复再生。

结论:脊髓Ⅱ号方剂可以促进损伤神经元的修复再生,具有良好的临床应用前景。

[关键词]:脊髓Ⅱ号脊髓损伤脊髓修复再生病理组织学

Pathohistological Study Of the Effect of SC-Ⅱ Decoction on Promoting Repair and Regeneration of In jured Spinal Cord

Abstract:

Aim To test and verify the therapeutic effect of Chinese herbs decoction "Spinal Cord Ⅱ (SC--Ⅱ)" on repair and regeneration of the spinal neurons.

Methods Experimental models of right hemitransection of spinal cord at T₁₂ were made in 18 Wistar rats and divided randomly into three groups: treated with SC--Ⅱ decoction, hydrocortisone and normal saline respectively. Four weeks later, pathohistological examination was made.

Results There were obvious therapeutic effects of the SC--Ⅱ decoction: reducing the injured area, inhibiting the proliferation of connective tissue and neuroglia, promoting repair and regeneration of nerve fibers and the perikaryon in the hemitransected cord.

Conclusion There is a good prospect for clinical application of SC--Ⅱ decoction with the promotion of the repair of the injured spinal neurons.

KEYWORDS:Chinese herbs SC--Ⅱ decoction Spinal cord injury repair and regeneration Pathohistological study

引用本文，请按以下格式著录参考文献：

中文格式:	韩凤岳,张凤绥,刘卫东.脊髓Ⅱ号治疗大鼠脊髓损伤的病理组织学研究[J].中国骨伤,1998,11(5):9~11
英文格式:	Han Fengyue,Zhang Fengsui,Liu Weidong.Pathohistological Study Of the Effect of SC-Ⅱ Decoction on Promoting Repair and Regeneration of In jured Spinal Cord[J].zhongguo gu shang / China J Orthop Trauma ,1998,11(5):9~11

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