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中药补骨丹治疗去卵巢大鼠骨质疏松的研究

Hits: 2908 Download times: 1227 Received:December 16, 1996

作者	Author	单位	Unit	E-Mail
夏志道	Xia Zhidao	同济医科大学附属协和医院,武汉430022	Union Hospital Tong ji Medical University Wuhan 430022
蔡国平	Cai Guoping	清华大学生物科学与技术系
常超英	Chang Chuoyinzg	中国中医研究院骨伤科研究所
吴文才		北京梵世生物高技术研究所
冯世纶		北京中日友好医院

期刊信息：《中国骨伤》1998年11卷，第2期，第16-19页

DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz

本文报道一种经生物化学增效的中药复方制剂“补骨丹”对卵巢切除大鼠骨质疏松模型的治疗。 6月龄雌性Wistar大鼠30只,手术切除双侧卵巢造成骨质疏松模型；另10只假手术手正常对照。去卵巢大鼠随机分为3组,以生理盐水、补骨丹、或己烯雌酚腹腔注射,1次/日,治疗8周。从生物力学、骨密度、骨组织形态等方面进行了研究。结果表明,补骨丹组股骨骨矿含量、生物力学性能均显着高于模型组,病理组织学观察结果与此相符。提示补骨丹是一种有研究和应用前景的制剂。

[关键词]:骨质疏松补骨丹生化增效大鼠

Study on the Effects of Bu Gu Dan in the Treatment of osteoporosis in Ovariectomized Rats

Abstract:The effects of Bu Gu Dan (BGD), a biochmlically synergic traditional Chinese herb preparation, in treatment of osteoporosis of ovariectomized rats have been studied. 40 female Wistar rats aged 6 months were used. 10 out of them, as normal group, were made a sham operation. 30 out of them were ovariectomized bilaterally to mould the models of osteoporosis, and then divided randomly into three groups: injected intraperitoneally Q. D. with normal saline, BGD, and diethylstilbestrol, respectively. After treating for & weeks, the biomechanical property, bone density, and histopathological changes were examined. The results showed that the bone mineral content and biomechanical property of femur in BGD group were higher significantly than that of model group, and the result of pathohistologlcal observation was in accordance with them. It is concluded that BGD is a preparation with good prospects for research and application.

KEYWORDS:Osteoporosis Bu Gu Dan Biomechanical synergics Rat

引用本文，请按以下格式著录参考文献：

中文格式:	夏志道,蔡国平,常超英,吴文才,冯世纶.中药补骨丹治疗去卵巢大鼠骨质疏松的研究[J].中国骨伤,1998,11(2):16~19
英文格式:	Xia Zhidao,Cai Guoping,Chang Chuoyinzg.Study on the Effects of Bu Gu Dan in the Treatment of osteoporosis in Ovariectomized Rats[J].zhongguo gu shang / China J Orthop Trauma ,1998,11(2):16~19

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