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糖皮质激素建立老年大鼠骨质疏松症模型的实验研究

Hits: 2378 Download times: 1538 Received:December 11, 1995 Revised:September 13, 1996

作者	Author	单位	Unit	E-Mail
陈东煜	ChenDongyu	上海宝钢冶金建设公司职工医院,200941	Hospital of Shanghai Bao-Steel Metal Constructive Cooperation 200941
沈培芝	ShenPeizhi	上海市中医药研究院骨伤科研究所
石印玉	ShiYinyu	上海市中医药研究院骨伤科研究所
徐宇		上海市中医药研究院骨伤科研究所

期刊信息：《中国骨伤》1997年10卷，第1期，第8-9页

DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz

通过对老年期前雄性SD大鼠肌注地塞米松注射液,利用糖皮质激素的促骨质吸收作用,观察了实验鼠的全身骨密度、骨小梁容积及生物力学抗弯强度三项指标在高、中、低三种剂量中的变化。结果表明,中剂量地多米松连续肌注6周后,骨的抗弯强度、骨密度及骨小梁容积都显著降低(P＜0.05),低剂量虽已有降低趋势,尚无统计学意义(P＞0.05)。认为用介乎中、高剂量之间的量0.25mg/100g体重每周2次,连续6周可建立老年性大鼠骨质疏松症模型。

[关键词]:糖皮质激素骨质疏松症病理模型

Experimental Research on the Establishment of Osteoprosis Model in Pregeriatic Rat with Glucocorticoid

Abstract:Owing to the effect of glucocorticoid,promting bone substance absorption,the male pregeriatic SD rats had different dosages(0.05,0.1,0.4 mg/100g BW),and thereafter,the changes in bone density of whole body, volume of bone trabeculae and intensity of anticurvation were observed.The experimental results demonstrated that all of these parameters are decreased significantly in middle dosage group (P<0.05);those parameters in low dosage group tend to decrease but without statistical significance (P>0.05). It is considered that the osteoporosis model in pregeriatic rats could be established by intramuscular injection of dexamethasone, in the dose of 0.25mg/100gBW, twice weekly,for 6 weeds.

KEYWORDS:Glucocorticoid Osteoporosis Pathologic model

引用本文，请按以下格式著录参考文献：

中文格式:	陈东煜,沈培芝,石印玉,徐宇.糖皮质激素建立老年大鼠骨质疏松症模型的实验研究[J].中国骨伤,1997,10(1):8~9
英文格式:	ChenDongyu,ShenPeizhi,ShiYinyu.Experimental Research on the Establishment of Osteoprosis Model in Pregeriatic Rat with Glucocorticoid[J].zhongguo gu shang / China J Orthop Trauma ,1997,10(1):8~9

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