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补肾健骨汤对膝关节病患者氧自由基代谢的影响

Hits: 4913 Download times: 1884 Received:January 05, 1995 Revised:January 06, 1996

作者	Author	单位	Unit	E-Mail
沈霖	Shen Lin	武汉同济医科大学附属协和医院	Xiehe Hospital,Tongji Medical University,Wuhan 430022
杨家玉		武汉同济医科大学附属协和医院	Xiehe Hospital,Tongji Medical University,Wuhan 430022
高兰		武汉同济医科大学附属协和医院	Xiehe Hospital,Tongji Medical University,Wuhan 430022

期刊信息：《中国骨伤》1996年9卷，第4期，第8-10页

DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz

对58例膝关节病患者用补肾健骨汤治疗前后的红细胞超氧化物歧化酶(SOD)及血清脂质过氧化物(LPO)含量进行了动态检测。结果：患者治疗前SOD活性低于正常,LPO含量高于正常(P均<0.01).经治疗病情好转者其氧自由基代谢指标相应改善,显效者恢复正常,无效者仍异常。提示氧自由基可能参入骨关节病的病理过程；补肾健骨汤治疗骨关节病的机理与其改善患者体内氧自由基代谢的紊乱状况有关。

[关键词]:补肾健骨汤骨关节病超氧化物歧化敏过氧化脂质氧自由基

Effect of Bushen Jiangu Tang on oxygen free radiCAI metabolism of patients with osteoarthritis of knee joint

Abstract:Fifty eight cases of osteoarthritis (OA) of knee joint were treated by oral taken Bushen Joamgi Tamg (BSJGT).Before and after treatment the observation of oxygen free radical metabolism have been taken through the activity of superoxide dismutase (SOD) of RBC and the content of lipid peroxide (LPO) of serum. The results showed that before treatment SOD activity decreased significantly and LPO content increased markedly in patients with OA than that in controls (P<0.01).After treatment with BSJGT by oral administration parameter of SOD and LPO had been shown relevent improvement in the remission patients and that in the obvious effective cases returned to normal(P>0.05)and that in ineffective cases remained abnormal (P<0.01).This preiminary study suggested that oxygen free radical might take part in the pathological process of OA and one of therapeutic mechanism of BSJGT is probably due to improving metabolic disorder of the oxygen free radical in patients with OA of knee joint.

引用本文，请按以下格式著录参考文献：

中文格式:	沈霖,杨家玉,高兰.补肾健骨汤对膝关节病患者氧自由基代谢的影响[J].中国骨伤,1996,9(4):8~10
英文格式:	Shen Lin.Effect of Bushen Jiangu Tang on oxygen free radiCAI metabolism of patients with osteoarthritis of knee joint[J].zhongguo gu shang / China J Orthop Trauma ,1996,9(4):8~10

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