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激素性股骨头缺血坏死发病机制的实验研究与临床治疗观察

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作者	Author	单位	Unit	E-Mail
王坤正	Wang Kun-zheng	西安医科大学第二附属医院 710004	Second Affiliated Hospital of Xian University of Medical Science 710004
贺西京		西安医科大学第二附属医院 710004	Second Affiliated Hospital of Xian University of Medical Science 710004
毛履真		西安医科大学第二附属医院 710004	Second Affiliated Hospital of Xian University of Medical Science 710004
陈君长		西安医科大学第二附属医院 710004	Second Affiliated Hospital of Xian University of Medical Science 710004
金辽沙		西安医科大学第二附属医院 710004	Second Affiliated Hospital of Xian University of Medical Science 710004
刘安庆		西安医科大学第二附属医院 710004	Second Affiliated Hospital of Xian University of Medical Science 710004
杨哲		西安医科大学第二附属医院 710004	Second Affiliated Hospital of Xian University of Medical Science 710004
兰斌尚		西安医科大学第二附属医院 710004	Second Affiliated Hospital of Xian University of Medical Science 710004

期刊信息：《中国骨伤》1993年6卷，第5期，第5-7页

DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz

采用日本白兔64只,随机分为两组,实验组每周皮下注射醋酸氢化可的松8mg/kg,对照组注射生理盐水0.32mg/kg。结果显示：激素药物应用能引起股骨头骨细胞发生脂肪变性和坏死,小血管脂肪栓塞。异常肥大的骨髓内脂肪细胞压迫股骨头内小静脉引起毛细血管血液瘀滞。毛细血管生长和再生受到抑制。

[关键词]:股骨头坏死醋酸氢化可的松病理学

Experimental study and Clinical observation on the mechanism of steriod induced ischemic necrosis of the femoral head

Abstract:Sixty-four Japanese White rabbits were randomly divided into two group: Hydrocortisone acetate of 8mg/kg were injected. Hypodermically to the experimental group and normal saline 0. 32mg/kg to the control group in the same way every week. The results showed that application of the steriod drug could produce fat degeneration and necrosis of osteocytes and fat embolism in the small blood vessels of the femoral head. The abnormal hypertrophied fat cells in the bone marrow compressed small veins in the femoral head to cause blood stasis of the capillaries. The growth and regeneration of the cappillary were inhibited.Clinically, 109 cases of steroid induced ischemic necrosis of femoral head were treated with repair of deformed head, filling cancellous bone into the necrotic area and grafting fibula with anastomosis of blood vessels. Followed up studies from 1-10 years postoperatively showed that the excellent and good rate was 86.6%.

KEYWORDS:Femoral head necrosis hydrocortisone acetate pathology

引用本文，请按以下格式著录参考文献：

中文格式:	王坤正,贺西京,毛履真,陈君长,金辽沙,刘安庆,杨哲,兰斌尚.激素性股骨头缺血坏死发病机制的实验研究与临床治疗观察[J].中国骨伤,1993,6(5):5~7
英文格式:	Wang Kun-zheng.Experimental study and Clinical observation on the mechanism of steriod induced ischemic necrosis of the femoral head[J].zhongguo gu shang / China J Orthop Trauma ,1993,6(5):5~7

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