| “肾主骨”的骨组织形态计量学基础实验研究综合报告 |
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| 期刊信息：《中国骨伤》1990年3卷，第6期，第1-5,32页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
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| 本实验以“肾主骨”理论为指导,通过系列动物实验、采取半自动骨组织图象分析技术研究探讨性激素水平下降引起骨组织结构改变的机理,及补肾药物对促进骨折愈合和对骨质疏松的治疗作用基础。结果表明,性激素水平下降导致骨量丢失、关节软骨变性,是由于骨吸收抑制因素减少,骨吸收活动增强,骨形成相对不足而使骨质疏松、骨折愈合迟缓。补“肾”中药黔岭藿制剂对骨骼组织结构具有明显的影响,可加强成骨细胞活性、增加成骨细胞数量、缩短吸收周期,从而维持了因性激素水平下降而诱发的骨结构改变趋于正常状态,同时也保持了骨量的稳定,从而促进了骨形成速度,骨量的增长及骨矿物质沉积率的提高。本研究给“肾主骨”理论提供了骨组织形态计量学的基础。 |
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| Experimental studies of bone Histomorphometric basis of Shen (肾) Zhu (主) Gu (骨) Theory |
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| Abstract:Shen Zhu Gu---a theory of the kidney dominatins the physiology of the bone---is one of the fundamental theories in the Traditional Chinese Medicine (TCM)Under the quidance of the theory,a series of experiments were performed including the studies of the sexual hormone and ELS---one of the TCMs which reinforces the vital energy of the kidney. It was found that the decrease in the sexual hormone could change the bony structure including the loss of bone mass, degeneration of the articular cartilage osteoporosis (because of the decrease in the resorption of the inhibitive factor. increase in the bone resorption and insufficience of booe formation. thus resulting in the formation of osteoporosis)and delay in bone healing; and that ELS preparation had a significant influence on the bony structure---such as the reinforcement of the activity and increase in the number of the osteoblasts and shortening of the bone resorption period, thereby resulting in the correction of the ossen change due to decrease in the sexual hormone into normal bony structure and the maintenance of the stability of the bone mass. It has been noted that the influence of ELS on the bone structure will be in the two respects: Firstly. it may regulate the level of the sexual hormone, giving an indirect effect on the bone: secondly, it directly effects the metabolic activity of the bone thereby promoting the bone formation, increasing in bone mass and in the bone mineralizing rate. ELS, therefor, seems to have an ideal therapeutic effect on the treatment of fractures and on the protection of osteoporotic model in the experimental study. It was believd thae bone histomorphometric study could provide some tasic evidence for the theory of Shen Zhu Gu of TCM |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 时光达,吴非.“肾主骨”的骨组织形态计量学基础实验研究综合报告[J].中国骨伤,1990,3(6):1~5,32 |
| 英文格式: | Shi Guangda,Wu Fei.Experimental studies of bone Histomorphometric basis of Shen (肾) Zhu (主) Gu (骨) Theory[J].zhongguo gu shang / China J Orthop Trauma ,1990,3(6):1~5,32 |
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