| 膝骨关节炎患者巨噬细胞趋化力与疾病严重程度的相关性 |
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投稿时间：2022-12-20
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| 作者 | Author | 单位 | Address | E-Mail |
| 解志波 |
XIE Zhi-bo |
深圳市宝安区福永人民医院骨二科, 广东 深圳 518103 |
Department of Second Orthopaedics, Fuyong People's Hospital, Shenzhen 518103, Guangdong, China |
3633461183@qq.com |
| 陈科明 |
CHEN Ke-ming |
深圳市宝安区福永人民医院骨二科, 广东 深圳 518103 |
Department of Second Orthopaedics, Fuyong People's Hospital, Shenzhen 518103, Guangdong, China |
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| 黄从伍 |
HUANG Cong-wu |
深圳市宝安区福永人民医院骨二科, 广东 深圳 518103 |
Department of Second Orthopaedics, Fuyong People's Hospital, Shenzhen 518103, Guangdong, China |
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| 陈林清 |
CHEN Lin-qing |
深圳市宝安区福永人民医院骨二科, 广东 深圳 518103 |
Department of Second Orthopaedics, Fuyong People's Hospital, Shenzhen 518103, Guangdong, China |
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| 欧阳凯 |
OUYANG Kai |
深圳市宝安区福永人民医院骨二科, 广东 深圳 518103 |
Department of Second Orthopaedics, Fuyong People's Hospital, Shenzhen 518103, Guangdong, China |
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| 彭庆星 |
PENG Qing-xing |
深圳市宝安区福永人民医院骨二科, 广东 深圳 518103 |
Department of Second Orthopaedics, Fuyong People's Hospital, Shenzhen 518103, Guangdong, China |
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| 期刊信息：《中国骨伤》2023年，第36卷，第6期，第514-518页 |
| DOI：10.12200/j.issn.1003-0034.2023.06.004 |
| 基金项目: |
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中文摘要:
目的：探讨膝骨关节炎（knee osteoarthritis，KOA）患者巨噬细胞趋化力增强情况，及与疾病严重程度的相关性。
方法：筛选2019年7月至2022年6月收治的80例KOA患者为观察组，并分为中度组29例、重度组30例和极重组21例。同期选入健康体检者30例作为对照组。检测各组巨噬细胞中核转录因子-κB （nuclear transcription factor-κB，NF-κB）、CXC趋化因子受体7（C-X-C chemokine receptor type 7，CXCR7）和CXC趋化因子配体12（C-X-C chemokine ligand 12，CXCL12）的基因表达；用视觉模拟量表评分（visual analogue scale，VAS）评价关节的疼痛程度；用膝骨关节学会评分系统（Knee Society score，KSS）评价关节功能；并进行分析。
结果：中度组、重度组、极重组的NF-κB、CXCR7和CXCL12表达均高于对照组；重度组、极重组的VAS、NF-κB、CXCR7和CXCL12表达均高于中度组，KSS低于中度组；极重组VAS、NF-κB、CXCR7和CXCL12表达高于重度组，KSS低于重度组（均P<0.01）。患者巨噬细胞中NF-κB、CXCR7和CXCL12表达均与VAS呈正相关，而与KSS呈负相关（P均<0.01）。患者巨噬细胞中NF-κB、CXCR7和CXCL12表达均与疾病严重程度呈正相关；排除传统因素（性别、年龄、病程）的影响，多元线性回归分析进一步显示NF-κB、CXCR7和CXCL12表达均与疾病严重程度仍呈正相关（P均<0.01）。
结论：KOA患者巨噬细胞趋化力随着病情加重而呈增强趋势，且与疼痛程度、功能受损程度均相关。 |
| 【关键词】膝骨关节炎 巨噬细胞 趋化 疾病严重程度 相关性 |
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| Correlation between macrophage chemotaxis and disease severity in patients with knee osteoarthritis |
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ABSTRACT
Objective To investigate the enhancement of macrophage chemotaxis in patients with knee osteoarthritis (KOA) and its correlation with the disease severity.
Methods Eighty patients with KOA admitted from July 2019 to June 2022 were enrolled as the observation group and divided into 29 cases of moderate group, 30 cases of severe group and 21 cases of extremely severe group. At the same time, 30 healthy subjects were included as the control group. The gene expressions of NF-κB, CXC chemokine receptor 7 (CXCR7) and CXC chemokine ligand 12 (CXCL12) in macrophages of each group were analyzed. Visual analogue scale(VAS) was used to evaluate the degree of joint pain. Joint function was evaluated by knee Joint Society Scoring system(KSS). Finally, data analysis was carried out.
Results The expression levels of NF-κB, CXCR7 and CXCL12 in moderate group, severe group and extreme recombination group were higher than those in control group. The VAS, the expression of NF-κB, CXCR7 and CXCL12 in the severe group and the extreme recombination group were higher than those in the moderate group, whereas KSS was lower than that in the moderate group. The VAS, expression levels of NF-κB, CXCR7 and CXCL12 in the extremely severe group were higher than those in the severe group, and KSS was lower than that in the severe group (all P<0.01). The expression levels of NF-κB, CXCR7 and CXCL12 in macrophages were positively correlated with VAS score, but negatively correlated with KSS(all P<0.01). The expression levels of NF-κB, CXCR7 and CXCL12 in macrophages were positively correlated with the severity of disease. After excluding the influence of traditional factors (gender, age and disease duration), multiple linear regression analysis further showed that the expression levels of NF-κB, CXCR7 and CXCL12 were still positively correlated with the severity of disease(all P<0.01).
Conclusion The chemotaxis of macrophages in patients with KOA increased with the aggravation of the disease, and was related to the degree of pain and function impairment. |
| KEY WORDS Knee osteoarthritis Macrophage Chemotaxis Disease severity Correlation |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 解志波,陈科明,黄从伍,陈林清,欧阳凯,彭庆星.膝骨关节炎患者巨噬细胞趋化力与疾病严重程度的相关性[J].中国骨伤,2023,36(6):514~518 |
| 英文格式: | XIE Zhi-bo,CHEN Ke-ming,HUANG Cong-wu,CHEN Lin-qing,OUYANG Kai,PENG Qing-xing.Correlation between macrophage chemotaxis and disease severity in patients with knee osteoarthritis[J].zhongguo gu shang / China J Orthop Trauma ,2023,36(6):514~518 |
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