| 胫骨骨折患者术后血清小凹蛋白-1蛋白含量与延迟愈合关系的探究 |
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投稿时间：2021-10-27
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| 作者 | Author | 单位 | Address | E-Mail |
| 丁涛 |
DING Tao |
中国人民解放军联勤保障部队第九〇一医院骨外科, 安徽 合肥 230031 |
Department of Orthopaedics, the 901st Hospital of Joint Logistics Support Force of PLA, Hefei 230031, Anhui, China |
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| 夏克 |
XIA Ke |
中国人民解放军联勤保障部队第九〇一医院骨外科, 安徽 合肥 230031 |
Department of Orthopaedics, the 901st Hospital of Joint Logistics Support Force of PLA, Hefei 230031, Anhui, China |
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| 陈前永 |
CHEN Qian-yong |
中国人民解放军联勤保障部队第九〇一医院骨外科, 安徽 合肥 230031 |
Department of Orthopaedics, the 901st Hospital of Joint Logistics Support Force of PLA, Hefei 230031, Anhui, China |
cqyiong@163.com |
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| 期刊信息：《中国骨伤》2022年，第35卷，第6期，第527-531页 |
| DOI：10.12200/j.issn.1003-0034.2022.06.005 |
| 基金项目: |
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中文摘要:
目的:探讨胫骨骨折患者切开复位内固定手术后血清小凹蛋白-1(caveolin-1)蛋白含量与延迟愈合的关系。
方法:自2018年4月至2020年6月收治接受切开复位内固定手术的134例胫骨骨折患者,根据骨折愈合情况分为延迟愈合组和正常愈合组。比较两组患者术前及术后1、4、8、12周时血清caveolin-1蛋白含量,采用Logistic回归模型分析骨折延迟愈合的影响因素,采用受试者工作特征(receiver operating characteristic,ROC)曲线分析血清caveolin-1蛋白对骨折延迟愈合的预测价值。
结果:骨折后4个月时随访评估愈合情况,正常愈合93例,延迟愈合41例。术后1、4、8、12周时,延迟愈合组血清caveolin-1蛋白含量均低于正常愈合组(P<0.05);延迟愈合组与正常愈合组在吸烟、糖尿病、开放性骨折、Gustlio分型Ⅲ型方面比较差异有统计学意义(P<0.05);经Logistic回归分析,吸烟、糖尿病、开放性骨折、Gustlio Ⅲ型骨折及术后4、8周时血清caveolin-1蛋白含量降低是骨折延迟愈合的危险因素(P<0.05);经ROC曲线分析,术后4、8周时血清caveolin-1蛋白含量对骨折延迟愈合具有预测价值,预测的最佳截断值分别为12.45、12.52 ng/ml,对应的灵敏度为45.34%、43.90%,特异性为80.65%、87.10%(P<0.05)。
结论:胫骨骨折患者切开复位内固定术后4、8周时血清caveolin-1蛋白含量降低与延迟愈合有关,术后4、8周时检测血清caveolin-1蛋白含量对延迟愈合具有预测价值。 |
| 【关键词】胫骨骨折|骨折切开复位|小凹蛋白-1|骨折愈合 |
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| Exploration of relationship between postoperative serum caveolin-1 contents and delayed healing of tibial fracture patients |
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ABSTRACT
Objective: To explore relationship between postoperative serum caveolin-1 contents after open reduction and internal fixation and delayed healing of tibial fracture patients.
Methods: From April 2018 to June 2020,134 tibial fracture patients underwent open reduction and internal fixation were included,and divided into delayed healing group and normal healing group according to fracture healing condition. Contents of serum caveolin-1 protein before operation,1,4,8,12 weeks after operation between two groups were compared. Influencing factors of delayed healing was analyzed by Logistic regression model,and predictive value of serum caveolin-1 protein on delayed healing was analyzed by receiver operating characteristic(ROC) curve.
Results: Fracture healing was evaluated at 4 months after fracture,93 patients healed well and 41 patients delayed heal. At 1,4,8 and 12 weeks,content of serum caveolin-1 protein in delayed healing group was lower than that of normal healing group(P<0.05). There were statistical difference in smoking,diabetes,open fracture and Gutlio Ⅲ fracture between delayed healing group and normal healing group(P<0.05). Smoking,diabetes,open fracture,Gustlio Ⅲ fracture,decrease of serum caveolin-1 protein at 4 and 8 weeks after operation were risk factor of delayed healing by Logistic analysis(P<0.05). By ROC curve analysis,content of serum caveolin-1 protein had predictive value for delayed fracture,the best cut-off values were 12.45 ng/ml and 12.52 ng/ml respectively,corresponding sensitivity were 45.34%,43.90%,and specificity were 80.65% and 87.10% (P<0.05).
Conclusion: Decrease of serum caveolin-1 protein content at 4 and 8 weeks after open reduction and internal fixation for tibia fracture patients were related with delayed healing. Detection of serum caveolin-1 protein content at 4 and 8 weeks after operation has predictive value for delayed healing. |
| KEY WORDS Tibial fracture|Open fracture reduction|Caveolin-1|Fracture healing |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 丁涛,夏克,陈前永.胫骨骨折患者术后血清小凹蛋白-1蛋白含量与延迟愈合关系的探究[J].中国骨伤,2022,35(6):527~531 |
| 英文格式: | DING Tao,XIA Ke,CHEN Qian-yong.Exploration of relationship between postoperative serum caveolin-1 contents and delayed healing of tibial fracture patients[J].zhongguo gu shang / China J Orthop Trauma ,2022,35(6):527~531 |
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