| 自噬在骨骼肌质量维持中的作用 |
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投稿时间：2021-03-20
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| 作者 | Author | 单位 | Address | E-Mail |
| 刘阿英 |
LIU A-ying |
安徽医科大学第二附属医院康复医学科, 安徽 合肥 230601 |
Department of Rehabilitation Medicine,the Second Hospital of Anhui Medical University,Hefei 230601,Anhui,China |
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| 张全兵 |
ZHANG Quan-bing |
安徽医科大学第二附属医院康复医学科, 安徽 合肥 230601 |
Department of Rehabilitation Medicine,the Second Hospital of Anhui Medical University,Hefei 230601,Anhui,China |
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| 周云 |
ZHOU Yun |
安徽医科大学第二附属医院康复医学科, 安徽 合肥 230601 |
Department of Rehabilitation Medicine,the Second Hospital of Anhui Medical University,Hefei 230601,Anhui,China |
zhoukeg@163.com |
| 王锋 |
and WANG Feng |
安徽医科大学第二附属医院康复医学科, 安徽 合肥 230601 |
Department of Rehabilitation Medicine,the Second Hospital of Anhui Medical University,Hefei 230601,Anhui,China |
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| 期刊信息：《中国骨伤》2022年，第35卷，第4期，第374-378页 |
| DOI：10.12200/j.issn.1003-0034.2022.04.015 |
| 基金项目:安徽医科大学转化医学研究生培养改革试点项目(编号:9101118101);安徽省重点研发计划项目(编号:201904a07020067) |
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| 中文摘要:作为人体重要的运动和能量代谢器官,骨骼肌质量的正常维持对于机体发挥正常的生理功能至关重要。自噬-溶酶体(autophagy-lysosome,AL)途径是一种在正常和病态细胞中普遍存在的生理或病理机制,对于维持细胞内蛋白质平衡,清除细胞内受损的细胞器,及维持内环境稳定起到关键作用。自噬过程的顺利进行需要经历多个步骤,在多重因子的协调作用下完成。自噬通过清除受损的肌原纤维和隔离的胞浆蛋白等细胞成分来维持健康机体的肌肉内稳态。自噬还可以提供细胞增殖所需的初始能量,促进损伤后肌肉的再生和重塑。同时,自噬失调也是导致年龄相关性骨骼肌萎缩的一个重要诱因。自噬可以影响骨骼肌对运动的反应,增加基础自噬水平有利于提高骨骼肌对运动的适应性。本文将自噬在骨骼肌质量维持中的作用与通路进行总结,以便为临床预防和治疗肌萎缩提供有效的康复策略。 |
| 【关键词】骨骼肌 肌萎缩 自噬 溶酶体 |
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| Role of autophagy in the maintenance of skeletal muscle mass |
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| ABSTRACT As an important exercise and energy metabolism organ of the human body,the normal maintenance of skeletal muscle mass is essential for the body to perform normal physiological functions. The autophagy-lysosome (AL) pathway is a physiological or pathological mechanism that is ubiquitous in normal and diseased cells. It plays a key role in the maintaining of protein balance,removing damaged organelles,and the stability of internal environment. The smooth progress of the autophagy process needs to go through multiple steps,which are completed under the coordinated action of multiple factors. Autophagy maintains the muscle homeostasis of a healthy body by removing cell components such as damaged myofibrils and isolated cytoplasmic proteins. Autophagy could also provide the initial energy required for cell proliferation,promote muscle regeneration and remodeling after injury. At the same time,autophagy disorder is also an important cause of age-related skeletal muscle atrophy. Autophagy could affect the response of skeletal muscle to exercise,and increasing the level of basic autophagy is beneficial to improve the adaptive response of skeletal muscle to exercise. This article summarizes the role and pathways of autophagy in the maintenance of skeletal muscle quality,in order to provide effective rehabilitation strategies for clinical prevention and treatment of muscle atrophy. |
| KEY WORDS Skeletal muscle Muscular atrophy Autophagy Lysosome |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 刘阿英,张全兵,周云,王锋.自噬在骨骼肌质量维持中的作用[J].中国骨伤,2022,35(4):374~378 |
| 英文格式: | LIU A-ying,ZHANG Quan-bing,ZHOU Yun,and WANG Feng.Role of autophagy in the maintenance of skeletal muscle mass[J].zhongguo gu shang / China J Orthop Trauma ,2022,35(4):374~378 |
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