| 间充质干细胞归巢及其在骨科疾病中的研究 |
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投稿时间：2019-12-10
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| 期刊信息：《中国骨伤》2020年，第33卷，第7期，第689-692页 |
| DOI：10.12200/j.issn.1003-0034.2020.07.020 |
| 基金项目:国家自然科学基金（编号：81874478）；湖南省研究生创新项目（编号：CX2018B475） |
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| 中文摘要:间充质干细胞（mesenchymal stem cells，MSCs）是近些年在骨科研究领域中治疗各种疾病很有吸引力和潜力的种子细胞。因MSCs具有向成骨细胞分化的特性，且前的研究主要集中在MSCs的成骨分化。随着研究的深入，逐渐发现MSCs归巢在骨形成和骨科疾病治疗中也起到重要作用。MSCs归巢是指MSCs离开原有的微环境（主要是骨髓）进入外周血循环，并迁出外周血管至组织损伤处的过程。MSCs归巢是骨形成的前提条件，只有MSCs首先归巢至损伤处后，进而分化为成骨细胞，才能参与骨组织的修复。促进MSCs归巢在骨质疏松症、骨折、骨缺损及颗粒磨损性骨溶解等骨科疾病治疗中已起到积极的作用。因此，进一步研究MSCs归巢将对治疗骨科疾病提供新的思路。 |
| 【关键词】间充质基质细胞 骨生成 综述 |
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| Study on MSCs homing and its research on osteodiseases |
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| ABSTRACT Mesenchymal stem cell (MSCs) has recently emerged as an appealing and potential therapeutic strategy to cure a diverse range of diseases in the orthopaedic field. Owing to its capacity of osteogenic differentiation,most of researches just focused on promoting MSC differentiation. With the in-depth study,MSCs homing is also a key issue for bone formation and bone diseases treatment,which have been described that MSCs mobilize from in situ environment (bone marrow) and migrate into injured tissues during the healing process through peripheral circulation. MSC homing is the incipient step of bone formation. MSCs need to firstly migrate to the bone surface and then differentiate into osteogenic cells to enhance bone repair. Promoting MSCs homing have been shown to improve recovery of several orthopedic diseases,such as osteoporosis,fracture,bone defect and wear-particle-related osteolysis. Therefore,further research on MSCs homing may provide a new thinking for treatment of osteoporosis. |
| KEY WORDS Mesenchymal stromal cells Osteogenesis Review |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 李汪洋,熊辉.间充质干细胞归巢及其在骨科疾病中的研究[J].中国骨伤,2020,33(7):689~692 |
| 英文格式: | LI Wang-yang,XIONG Hui.Study on MSCs homing and its research on osteodiseases[J].zhongguo gu shang / China J Orthop Trauma ,2020,33(7):689~692 |
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