| 富血小板血浆注射治疗萎缩性骨折不愈合 |
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投稿时间：2019-06-20
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| 作者 | Author | 单位 | Address | E-Mail |
| 王林 |
WANG Lin |
潞安集团总医院骨一科, 山西 长治 046000 |
The First Department of Orthopaedics, Luan Group General Hospital, Changzhi 046000, Shanxi, China |
13835581394@163.com |
| 杨建业 |
YANG Jian-ye |
潞安集团总医院骨一科, 山西 长治 046000 |
The First Department of Orthopaedics, Luan Group General Hospital, Changzhi 046000, Shanxi, China |
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| 张秉文 |
ZHANG Bing-wen |
潞安集团总医院骨一科, 山西 长治 046000 |
The First Department of Orthopaedics, Luan Group General Hospital, Changzhi 046000, Shanxi, China |
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| 祁志强 |
QI Zhi-qiang |
潞安集团总医院骨一科, 山西 长治 046000 |
The First Department of Orthopaedics, Luan Group General Hospital, Changzhi 046000, Shanxi, China |
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| 宋俊生 |
SONG Jun-sheng |
潞安集团总医院骨一科, 山西 长治 046000 |
The First Department of Orthopaedics, Luan Group General Hospital, Changzhi 046000, Shanxi, China |
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| 期刊信息：《中国骨伤》2020年，第33卷，第3期，第261-264页 |
| DOI：10.12200/j.issn.1003-0034.2020.03.015 |
| 基金项目: |
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中文摘要:
目的：探讨富血小板血浆（platelet-rich plasma，PRP）注射治疗萎缩性骨折不愈合的临床疗效。
方法：自2015年3月至2017年3月采用PRP注射治疗15例萎缩性骨折不愈合患者，其中男10例，女5例；年龄23~56（40.0±9.1）岁；不愈合时间6~14（8.87±2.45）个月。抽取外周血60~100 ml，制备PRP，PRP血小板计数587~1 246（947.13±158.58）×109/L。透视定位下于骨折断端注射PRP 13~20 ml，分别于治疗后的第1、2周各注射1次，每月复查1次。观察术后患肢是否有短缩、成角、旋转畸形等并发症，并对其影像学检查进行评估。
结果：所有患者获得随访，时间6~12（6.8±2.1）个月。治疗后患肢均无短缩、成角、旋转畸形等并发症发生。13例患者骨折愈合，愈合时间4~6（4.8±0.7）个月；2例患者12个月随访时完全无骨痂形成，其中1例治疗期间螺钉松动；其余病例均无并发症。
结论：萎缩性骨折不愈合内固定术后骨折断端稳定是局部PRP注射的适应证。PRP治疗萎缩性骨折不愈合局麻穿刺下即可完成，操作安全、疗效可靠。 |
| 【关键词】富血小板血浆 注射 萎缩 骨折 |
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| Platelet-rich plasma injection for the treatment of atrophic fracture nonunion |
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ABSTRACT
Objective: To explore clinical effects of platelet-rich plasma(PRP) injection in treating atrophic fracture nonunion.
Methods: From March 2015 to March 2017,15 patients with atrophic fracture nonunion were treated with PRP injection,including 10 males and 5 females,aged from 23 to 56 years old with an average age of (40.0±9.1) years old,the time of fracture nonunion ranged from 6 to 14 months with an average of (8.87±2.45) months. Preparing PRP by extracting 60 to 100 ml peripheral blood. PRP platelet count ranged from 587 to 1 246 with an average of(947.13±158.58)×109/L. Under the perspective,13 to 20 ml PRP were injected into the fracture end,and each injection was performed once on the first and the second week of the treatment. Complications such as whether the limb was shortened,angulation,and rotational deformity and radiological examination were observed.
Results: All patients were followed up from 6 to 12 months with an average of(6.8±2.1) months. No shortening,angulation,and rotational deformity occurred. Thirteen patients had fracture healing,the time ranged from 4 to 6 months with an average of (4.8±0.7) months. Two patients had no completely porosis at 12 months during following-up,and 1 patient occurred bolt loose. Other patients had no complications.
Conclusion: The stability of fracture ends of atrophic fracture nonunion after internal fixation is an indication for local PRP injection. PRP treatment for atrophic fractures could completed under local anesthesia,and it has advantages of safe operation and reliable efficacy. |
| KEY WORDS Platelet-rich plasma Injections Atrophy Fractures |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 王林,杨建业,张秉文,祁志强,宋俊生.富血小板血浆注射治疗萎缩性骨折不愈合[J].中国骨伤,2020,33(3):261~264 |
| 英文格式: | WANG Lin,YANG Jian-ye,ZHANG Bing-wen,QI Zhi-qiang,SONG Jun-sheng.Platelet-rich plasma injection for the treatment of atrophic fracture nonunion[J].zhongguo gu shang / China J Orthop Trauma ,2020,33(3):261~264 |
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