| 诱导膜技术治疗大段骨缺损研究进展 |
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投稿时间：2017-08-20
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| 作者 | Author | 单位 | Address | E-Mail |
| 金志超 |
JIN Zhi-chao |
广州中医药大学, 广东 广州 510405 |
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| 蔡群斌 |
CAI Qun-bin |
广州中医药大学第一附属医院, 广东 广州 510405 |
Department of Traumatic Orthopedics, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China |
caiqunbin@126.com |
| 曾志奎 |
ZENG Zhi-kui |
广州中医药大学, 广东 广州 510405 |
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| 李定 |
LI Ding |
广州中医药大学, 广东 广州 510405 |
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| 李悦 |
LI Yue |
广州中医药大学第一附属医院, 广东 广州 510405 |
Department of Traumatic Orthopedics, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China |
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| 黄培镇 |
HUANG Pei-zhen |
广州中医药大学第一附属医院, 广东 广州 510405 |
Department of Traumatic Orthopedics, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China |
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| 郑晓辉 |
ZHENG Xiao-hui |
广州中医药大学第一附属医院, 广东 广州 510405 |
Department of Traumatic Orthopedics, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China |
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| 期刊信息：《中国骨伤》2018年，第31卷，第5期，第488-492页 |
| DOI：10.3969/j.issn.1003-0034.2018.05.018 |
| 基金项目:国家自然科学基金资助项目（编号：8160150894）；广东省中医药管理局项目（编号：20161135，20161129） |
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| 中文摘要:由创伤、骨髓炎、肿瘤引起的大段骨缺损的治疗一直是临床治疗的难点，以往针对大段骨缺损的治疗存在诸多修复重建的方法，但是存在技术治疗周期长、对技术要求高、较易出现骨折不愈合等缺点。2000年Masquelet报道了诱导膜技术以后，该技术被广泛应用于治疗创伤、骨髓炎、肿瘤引起的大段骨缺损，并获得了良好的疗效。其具有疗程短、愈合率高、操作简便，易于掌握等优点。诱导膜具有独特的结构特征和生物学特性，膜内包含的多种促成骨因子，如血管内皮生长因、骨形态发生蛋白－2、转化生长因子－β1等，可促进成骨，加速骨愈合。随着诱导膜技术的不断发展，铰刀冲洗抽吸技术、组织工程技术、内固定技术等技术的运用可以为缺损区提供骨源、促进骨缺损重建、改善远期肢体功能，减少并发症。本文回顾性的总结了Masquelet技术在治疗大段骨缺损中的实验研究和临床研究进展。 |
| 【关键词】诱导膜 骨缺损 综述文献 |
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| Research progress on induced membrane technique for the treatment of segmental bone defect |
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| ABSTRACT Treatment of large bone defects caused by trauma, osteomyelitis, and tumors has been a major challenge in clinical. In the past, there have been many ways to repair and reconstruct the large bone defects. However, there is a long period of treatment, high technical requirement and complications such as ununion. After Masquelet reported the induced membrane technology in 2000, the technique was widely used in treatment of trauma, osteomyelitis, and large bone defects caused by tumors.it has been obtained good results.It has the advantages of short course, high healing rate, easy operation and easy to master. The induced membrane has unique structural characteristics and biological characteristics. There are many kinds of osteogenic factors that are included in the membrane, such as vascular endothelial growth factor, and morphogenetic protein-2, transforming growth factor-β1, etc. These osteogenic factors contribute to accelerate bone healing. With the development of induced membrane technology. The technology of Reamer Irrigator Aspirator technology, engineering tissue technology and internal fixation is used in clinic.It can provide bone source, promote bone defect reconstruction, improve long-term limb function and reduce complications.This paper retrospectively summarizes the experimental research and clinical progress of Masquelet technique in the treatment of large bone defects. |
| KEY WORDS Induced membrane Bone defect Review literature |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 金志超,蔡群斌,曾志奎,李定,李悦,黄培镇,郑晓辉.诱导膜技术治疗大段骨缺损研究进展[J].中国骨伤,2018,31(5):488~492 |
| 英文格式: | JIN Zhi-chao,CAI Qun-bin,ZENG Zhi-kui,LI Ding,LI Yue,HUANG Pei-zhen,ZHENG Xiao-hui.Research progress on induced membrane technique for the treatment of segmental bone defect[J].zhongguo gu shang / China J Orthop Trauma ,2018,31(5):488~492 |
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