| 牵张应变刺激对软骨增殖及分化和细胞基质影响的研究进展 |
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投稿时间：2017-02-20
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| 作者 | Author | 单位 | Address | E-Mail |
| 门亚勋 |
MEN Ya-xun |
山西医科大学第二医院骨关节科 山西省骨与软组织损伤修复山西省重点实验室, 山西 太原 030001 |
Department of Orthopaedic Surgery, the Second Affiliated Hospital of Shanxi Medical University, Taiyuang 030001, Shanxi, China |
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| 赵永亮 |
ZHAO Yong-liang |
山西医科大学第二医院骨关节科 山西省骨与软组织损伤修复山西省重点实验室, 山西 太原 030001 |
Department of Orthopaedic Surgery, the Second Affiliated Hospital of Shanxi Medical University, Taiyuang 030001, Shanxi, China |
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| 程相允 |
CHENG Xiang-yun |
山西医科大学第二医院骨关节科 山西省骨与软组织损伤修复山西省重点实验室, 山西 太原 030001 |
Department of Orthopaedic Surgery, the Second Affiliated Hospital of Shanxi Medical University, Taiyuang 030001, Shanxi, China |
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| 曹万全 |
CAO Wan-quan |
山西医科大学第二医院骨关节科 山西省骨与软组织损伤修复山西省重点实验室, 山西 太原 030001 |
Department of Orthopaedic Surgery, the Second Affiliated Hospital of Shanxi Medical University, Taiyuang 030001, Shanxi, China |
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| 王刚 |
WANG Gang |
山西医科大学第二医院骨关节科 山西省骨与软组织损伤修复山西省重点实验室, 山西 太原 030001 |
Department of Orthopaedic Surgery, the Second Affiliated Hospital of Shanxi Medical University, Taiyuang 030001, Shanxi, China |
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| 杨自权 |
YANG Zi-quan |
山西医科大学第二医院骨关节科 山西省骨与软组织损伤修复山西省重点实验室, 山西 太原 030001 |
Department of Orthopaedic Surgery, the Second Affiliated Hospital of Shanxi Medical University, Taiyuang 030001, Shanxi, China |
yzqonline@126.com |
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| 期刊信息：《中国骨伤》2017年，第30卷，第7期，第675-679页 |
| DOI：10.3969/j.issn.1003-0034.2017.07.020 |
| 基金项目:2015年山西省基础研究计划项目（编号：2015011111） |
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| 中文摘要:力学刺激广泛存在并参与调节机体内多种细胞的生物行为。其中牵张应变作为机体内细胞常见的一种受力模式，广泛存在于如骨与软骨、肌腱、心肺血管等多种器官。近年来随着生物力学研究的发展，多种力学加载装置应运而生，用于模拟体内复杂的力学刺激来提供包括等轴、单轴以及多种类型的力学波形的牵张应变刺激，这对生物力学的研究是一个巨大的促进。多项研究已发现牵张应变刺激可引起受力细胞的增殖、凋亡、分化和基质等的改变，但是对于同种细胞不同类型牵张应变刺激可以出现多种甚至是相反的实验结果，该文就针对牵张应变对成软骨的增殖、分化和基质的影响略做综述。了解这些特性，将对生物力学刺激下细胞增殖与分化的机制及疾病的预防和治疗有着重要的意义。 |
| 【关键词】牵张应变 软骨 分化 增殖 细胞周基质 综述文献 |
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| Research progress on the effects of the tensile strain stimulation on proliferation differention and pericellular matrix of cartilage |
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| ABSTRACT Mechanical stimulation widely exists in the body and participates in adjusting biological behavior of many kinds of cells. As a common stress pattern in the body,the tensile strain widely exists in many organs,such as bone and cartilage,muscle tendon,cardiac and pulmonary vessels,and so on. In recent years,with the development of the researches of biomechanics,a variety of mechanical loading devices,which are used to simulate the complex mechanical stimulation in the body to provide the tensile strain including the isometric,uniaxial and various types of mechanical waveform,came into being. This is a huge boost to biomechanical research. Many researchers have found that the tensile strain stimulation can lead to the transformation of proliferation,differentiation and apoptosis of cells and change of cell matrix. However,for the same kind of cells,different kinds of tensile strain stimulation can lead to different and even the contrary results. In this paper,the effects of the tensile strain on the proliferation,differentiation and matrix of cartilage were reviewed. Understanding these characteristics will have important implications for the mechanism of cell proliferation and differentiation under the biomechanic stimulation and the prevention and treatment of diseases. |
| KEY WORDS Tensile strain Cartilage Proliferation Differentiation Pericellular matrix Review literature |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 门亚勋,赵永亮,程相允,曹万全,王刚,杨自权.牵张应变刺激对软骨增殖及分化和细胞基质影响的研究进展[J].中国骨伤,2017,30(7):675~679 |
| 英文格式: | MEN Ya-xun,ZHAO Yong-liang,CHENG Xiang-yun,CAO Wan-quan,WANG Gang,YANG Zi-quan.Research progress on the effects of the tensile strain stimulation on proliferation differention and pericellular matrix of cartilage[J].zhongguo gu shang / China J Orthop Trauma ,2017,30(7):675~679 |
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