| 人工关节置换术后磨损颗粒与假体周围骨溶解的研究进展 |
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投稿时间：2016-01-04
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| 期刊信息：《中国骨伤》2016年，第29卷，第10期，第968-972页 |
| DOI：10.3969/j.issn.1003-0034.2016.10.017 |
| 基金项目:高等学校博士学科点专项科研基金资助课题（编号：20133322120004）；GK2015年第1批创新团队引进和培育专项资金（编号：2015R410020） |
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| 中文摘要:人工关节置换术后磨损颗粒的产生是导致假体周围骨溶解的重要影响因素。目前研究认为磨损颗粒导致假体周围骨溶解的主要原因与植入假体的材料以及其产生的磨损颗粒通过各种作用对相关细胞如巨噬细胞、成骨细胞、破骨细胞等的刺激有关，诱导产生多种炎性细胞因子，激活和开放细胞信号和通路，产生长期慢性的炎症，导致假体周围骨溶解。为此，本文主要研究不同类型的磨损颗粒对假体周围骨溶解的影响，以及磨损颗粒在假体周围骨溶解进展过程中的机制，并且由此探讨如何减少磨损颗粒的产生以及阻断其在骨溶解进程的作用，以此来达到预防和治疗假体周围骨溶解的目的。 |
| 【关键词】磨损颗粒 人工关节 骨溶解 细胞因子类 |
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| Research progress on wear particles and periprosthetic osteolysis after artificial joint replacement |
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| ABSTRACT It is an important influencing factor that the generated wear particles lead to periprosthetic osteolysis after artificial joint replacement. Current research suggests that the primary cause of wear particles results in periprosthetic osteolysis is relate to the prosthetic materials and the stimulations because of these materials generated wear particles to relevant cells such as macrophage,osteoblast,osteoclast. Induced a variety of inflammatory cytokines,activating and openning the cell signal and channels,producing the long-term chronic inflammation leads to periprosthetic osteolysis. Therefor,the paper mainly studies the different types of wear particles influence on periprosthetic osteolysis,and the wear particles around the periprosthetic osteolysis mechanism in the process of progress,moreover,to explore how to reduce the occurrence of wear particles and blocking its role in the periprosthetic osteolysis,in order to achieve the purpose of prevention and treatment of periprosthetic osteolysis. |
| KEY WORDS Wear particles Joint prosthesis Osteolysis Cytokines |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 蒋营军,吴连国.人工关节置换术后磨损颗粒与假体周围骨溶解的研究进展[J].中国骨伤,2016,29(10):968~972 |
| 英文格式: | JIANG Ying-jun,WU Lian-guo.Research progress on wear particles and periprosthetic osteolysis after artificial joint replacement[J].zhongguo gu shang / China J Orthop Trauma ,2016,29(10):968~972 |
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