| 氨甲环酸在全膝关节置换术中应用策略的研究进展 |
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投稿时间：2015-10-20
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| 作者 | Author | 单位 | Address | E-Mail |
| 姬健钧 |
JI Jian-jun |
山西医科大学第二医院骨科, 山西 太原 030001 |
Department of Orthopaedics, the Second Hospital Affiliated to Shanxi Medical Univeristy, Taiyuan 030001, Shanxi, China |
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| 杨自权 |
YANG Zi-quan |
山西医科大学第二医院骨科, 山西 太原 030001 |
Department of Orthopaedics, the Second Hospital Affiliated to Shanxi Medical Univeristy, Taiyuan 030001, Shanxi, China |
yzqonline@126.com |
| 赵永亮 |
ZHAO Yong-liang |
山西医科大学第二医院骨科, 山西 太原 030001 |
Department of Orthopaedics, the Second Hospital Affiliated to Shanxi Medical Univeristy, Taiyuan 030001, Shanxi, China |
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| 谭利 |
TAN Li |
山西医科大学第二医院骨科, 山西 太原 030001 |
Department of Orthopaedics, the Second Hospital Affiliated to Shanxi Medical Univeristy, Taiyuan 030001, Shanxi, China |
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| 期刊信息：《中国骨伤》2016年，第29卷，第10期，第963-967页 |
| DOI：10.3969/j.issn.1003-0034.2016.10.016 |
| 基金项目: |
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| 中文摘要:氨甲环酸作为一种抗纤维蛋白溶解药用于减少全膝关节置换术中术后失血量是近年来研究的热点问题，对全膝关节置换术后患者的失血量、血红蛋白含量、输血率等其他相关指标的影响被大量学者研究及探讨。但如何安全、有效地应用氨甲环酸，目前还没有一种金标准策略。根据不同的用药剂量，氨甲环酸可以按药物体重比例使用或直接1.5 g或3.0 g使用；根据不同的给药途径，氨甲环酸可以静脉滴注、局部应用以及口服用药；根据不同的使用时机，氨甲环酸可以术前、术中、术后或联合使用。在不增加全膝关节置换术后血栓形成概率的条件下，选择更为科学的使用方法来发挥氨甲环酸的最大效用，是近来研究的热点。 |
| 【关键词】氨甲环酸 关节成形术,置换,膝 应用策略 血栓形成 |
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| Research progress on tranexamic acid application strategy in total knee arthroplasty |
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| ABSTRACT Tranexamic acid(TXA) as an antifibrinolytic drugs used to reduce the total knee arthroplasty(TKA) postoperative blood loss is a hot issue in recent years. Such as blood loss,hemoglobin,transfusion rate and other relevant indexs effected by the impact of total knee replacement have been studied and investigated by many scholars. There is no a gold standard about how to safely and effectively apply the TXA. Depending on the dose,TXA may be used by body weight or using 1.5 g or 3.0 g directly. Depending on the different route of administration,TXA may be intravenous infusion,topical application and oral medication. Depending on the using opportunity,TXA can be used preoperative,intraoperative,postoperative or combined application with different times. Without any increase in the chances of thrombosis after TKA,choosing the more scientific instructions to play the greatest utility TXA is a hot issue recently. |
| KEY WORDS Tranexamic acid Arthroplasty,replacement,knee Application strategy Thrombosis |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 姬健钧,杨自权,赵永亮,谭利.氨甲环酸在全膝关节置换术中应用策略的研究进展[J].中国骨伤,2016,29(10):963~967 |
| 英文格式: | JI Jian-jun,YANG Zi-quan,ZHAO Yong-liang,TAN Li.Research progress on tranexamic acid application strategy in total knee arthroplasty[J].zhongguo gu shang / China J Orthop Trauma ,2016,29(10):963~967 |
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