| 超选动脉骨髓基质干细胞灌注治疗非创伤性股骨头坏死中长期疗效分析 |
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投稿时间：2013-08-12
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| 期刊信息：《中国骨伤》2014年，第27卷，第7期，第565-569页 |
| DOI：10.3969/j.issn.1003-0034.2014.07.008 |
| 基金项目:浙江省自然科学基金资助重大和重点项目（编号：Z303656）；高等学校博士学科点专项科研基金（编号：20060344003）；浙江省中管局资助项目（编号：2007GA021）；浙江省中管局重点项目（编号：2011ZZ005） |
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中文摘要:
目的：研究骨髓基质干细胞经超选动脉灌注治疗非创伤性股骨头坏死的中长期疗效。
方法：回顾性分析2000年1月至2004年12月接受超选动脉骨髓基质干细胞灌注治疗且随访资料完整的62例78髋非创伤性股骨头坏死患者，男35例43髋，女27例35髋；年龄22～54岁，平均36.3岁。根据术前影像学资料示ARCOⅠ期16髋，Ⅱ期52髋，Ⅲa期10髋；术前Harris评分为（64.94±8.12）分。分析患者末次随访的Harris评分，影像学变化，DSA血管变化。
结果：患者术后随访9～13年，平均11年。共18髋接受人工关节置换，术前ARCOⅠ、Ⅱ期共10髋行人工关节置换，Ⅲa期8髋行人工关节置换。末次随访Harris评分为（71.21±10.19）分，较术前有明显提高。DSA可见供应股骨头的血管有增粗、增多。
结论：超选动脉骨髓基质干细胞灌注能有效治疗ARCOⅠ、Ⅱ期非创伤性股骨头坏死，可使旋股内动脉及其分支有增粗、增多表现。 |
| 【关键词】骨髓基质干细胞 股骨头坏死 放射学，介入性 |
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| Treatment of non-traumatic femoral head avascular necrosis by perfusion of bone marrow stromal stem cells through optional artery |
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ABSTRACT
Objective: To study the medium and long term effects of perfusion of bone marrow stromal stem cells through optional artery for the treatment of non-traumatic femoral head avascular necrosis.
Methods: From January 2000 to December 2004,62 cases(78 hips) with non-traumatic femoral head necrosis accepted optional artery marrow stromal stem cells infusion treatment and had complete follow-up data,including 43 hips of 35 males and 35 hips of 27 females with an average age of 36.3 years old (22 to 54). According to preoperative imaging data,16 hips were ARCOⅠstage,52 hips were Ⅱstage,10 hips were Ⅲa stage. Harris score was 64.94 ±8.12 preoperatively. Postoperative Harris score at the last follow-up,imaging changes,DSA vascular changes were analysis.
Results: The patients were followed up for 9 to 13 years (means 11 years). By the end of the follow-up,a total of 18 hips got artificial joint replacement,10 hips of preoperative ARCOⅠ,Ⅱperiod got artificial hip joint replacement,8 hips of Ⅲa period got hip artificial joint replacement. Harris score was 71.21±0.19 at the end of the follow-up,it was obviously enhanced compared with preoperative. DSA showed blood vessels of supply the femoral head increased thickening.
Conclusion: Perfusion of bone marrow stromal stem cells through optional artery can effective treat non-traumatic femoral head necrosis of ARCO Ⅰ,Ⅱ period,it can make the femoral circumflex artery and its branches increased thickening. |
| KEY WORDS Bone marrow stromal stem cells Femur head necrosis Radiology,interventional |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 童培建,叶福生,张善星,厉驹,刘新奇.超选动脉骨髓基质干细胞灌注治疗非创伤性股骨头坏死中长期疗效分析[J].中国骨伤,2014,27(7):565~569 |
| 英文格式: | TONG Pei-jian,YE Fu-sheng,ZHANG Shan-xing,LI Ju,LIU Xin-qi.Treatment of non-traumatic femoral head avascular necrosis by perfusion of bone marrow stromal stem cells through optional artery[J].zhongguo gu shang / China J Orthop Trauma ,2014,27(7):565~569 |
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