| 初次创伤骨折术后和二次创伤骨折术后机体凝血状态变化的差异性研究 |
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投稿时间：2013-02-25
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| 作者 | Author | 单位 | Address | E-Mail |
| 李彦贵 |
LI Yan-gui |
山西医科大学第二医院骨科, 山西 太原 030001 |
Department of Orthopaedics, the Second Hospital of Shanxi Medical Univeristy, Taiyuan 030001, Shanxi, China |
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| 马泽龙 |
MA Ze-long |
山西医科大学第二医院骨科, 山西 太原 030001 |
Department of Orthopaedics, the Second Hospital of Shanxi Medical Univeristy, Taiyuan 030001, Shanxi, China |
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| 张蜀华 |
ZHANG Shu-hua |
山西医科大学第二医院骨科, 山西 太原 030001 |
Department of Orthopaedics, the Second Hospital of Shanxi Medical Univeristy, Taiyuan 030001, Shanxi, China |
zhangshuhuazsh@163.com |
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| 期刊信息：《中国骨伤》2013年，第26卷，第11期，第932-934页 |
| DOI：10.3969/j.issn.1003-0034.2013.11.013 |
| 基金项目: |
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中文摘要:
目的：通过比较初次骨折与二次骨折术后机体凝血状态的变化，探讨骨折手术病史对于二次骨折后机体凝血状态的影响。
方法：选新西兰大兔10只，5～6月龄，雌雄各半，体重2.4～2.6 kg，无孕。先制作初次创伤骨折术后模型，12周后再进行二次创伤骨折术后造模，分别于两次骨折术后1 d、5 d取静脉血测量血浆凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）、纤维蛋白原（FIB）及D-二聚体（D-D） 5个指标，比较两次骨折术后同一时间各指标的变化。
结果：二次创伤骨折术后1 d与初次创伤骨折术后1 d比较，PT、APTT值差异无统计学意义 （P >0.05），TT、FIB、D-D值均升高，差异有统计学意义（P<0.05）；二次创伤骨折术后5 d与初次创伤骨折术后5 d比较，PT值差异无统计学意义 （P >0.05），APTT、TT、FIB、D-D值均升高，差异有统计学意义（P<0.05）.
结论：骨折手术病史使二次创伤骨折后血液更加处于高凝状态。 |
| 【关键词】凝血状态 凝血酶原时间 活化部分凝血活酶时间 凝血酶时间 纤维蛋白原 D-二聚体 |
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| Differences in the changes of blood clotting state after initial trauma fractures and twice trauma fractures |
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ABSTRACT
Objective: To compare changes of blood clotting state after initial trauma fractures and twice trauma fractures,investigate the effect of fracture history to the state of the blood clotting after secondary trauma fractures.
Methods: Thirty New Zealand rabbits were selected,aged 5-6 months,males and females unlimited,weighted 2.4-2.6 kg,non-pregnant. Postoperative model of initial trauma fractures was established,and then postoperative model after twice trauma fractures was built. Prothrombin time (PT),activated partial thromboplastin time (APTT),thrombin time (TT),fiber fibrinogen (FIB) and D-dimer (DD) were detected by venous blood at 1 day and 5 days after surgery. Changes of indicators were compared between after twice fractures at the same time.
Results: Comparing with 1 day after the secondary trauma fracture and initial trauma fracture surgery,PT,APTT values showed no significant difference (P >0.05),TT,FIB,DD values were increased,and the difference was statistically significant (P<0.05); Comparing with 5 days after the secondary trauma fracture and initial trauma fracture surgery,PT values showed no significant difference(P >0.05),APTT,TT,FIB,DD values were increased,and the difference was statistically significant(P<0.05).
Conclusion: Blood after the secondary trauma fractures is in hypercoagulable state after fracture surgery. |
| KEY WORDS Thrombin Prothrombin time Partial thromboplastin time Thrombin time Fibrinogen D-dimer |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 李彦贵,马泽龙,张蜀华.初次创伤骨折术后和二次创伤骨折术后机体凝血状态变化的差异性研究[J].中国骨伤,2013,26(11):932~934 |
| 英文格式: | LI Yan-gui,MA Ze-long,ZHANG Shu-hua.Differences in the changes of blood clotting state after initial trauma fractures and twice trauma fractures[J].zhongguo gu shang / China J Orthop Trauma ,2013,26(11):932~934 |
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