| 骨碎补总黄酮对胶原诱导性关节炎大鼠关节骨破坏影响的实验研究 |
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投稿时间：2012-10-15
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| 作者 | Author | 单位 | Address | E-Mail |
| 高华利 |
GAO Hua-li |
上海光华中西医结合医院脊柱外科, 上海 200052 |
Department of Spinal Surgery, Guanghua Integrated Traditional and Western Medical Hospital, Shanghai 200052, China |
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| 肖涟波 |
XIAO Lian-bo |
上海光华中西医结合医院脊柱外科, 上海 200052 |
Department of Spinal Surgery, Guanghua Integrated Traditional and Western Medical Hospital, Shanghai 200052, China |
xlb@medmail.com.cn |
| 张子峰 |
ZHANG Zi-feng |
上海光华中西医结合医院脊柱外科, 上海 200052 |
Department of Spinal Surgery, Guanghua Integrated Traditional and Western Medical Hospital, Shanghai 200052, China |
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| 欧阳桂林 |
OUYANG Gui-lin |
上海光华中西医结合医院脊柱外科, 上海 200052 |
Department of Spinal Surgery, Guanghua Integrated Traditional and Western Medical Hospital, Shanghai 200052, China |
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| 黄新星 |
HUANG Xin-xing |
上海光华中西医结合医院脊柱外科, 上海 200052 |
Department of Spinal Surgery, Guanghua Integrated Traditional and Western Medical Hospital, Shanghai 200052, China |
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| 李宁丽 |
LI Ning-li |
上海市免疫学研究所, 上海 200025 |
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| 胡军林 |
HU Jun-lin |
上海光华中西医结合医院脊柱外科, 上海 200052 |
Department of Spinal Surgery, Guanghua Integrated Traditional and Western Medical Hospital, Shanghai 200052, China |
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| 黄志明 |
HUANG Zhi-ming |
上海光华中西医结合医院脊柱外科, 上海 200052 |
Department of Spinal Surgery, Guanghua Integrated Traditional and Western Medical Hospital, Shanghai 200052, China |
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| 黄正 |
HUANG Zheng |
上海光华中西医结合医院脊柱外科, 上海 200052 |
Department of Spinal Surgery, Guanghua Integrated Traditional and Western Medical Hospital, Shanghai 200052, China |
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| 解骏 |
XIE Jun |
上海光华中西医结合医院脊柱外科, 上海 200052 |
Department of Spinal Surgery, Guanghua Integrated Traditional and Western Medical Hospital, Shanghai 200052, China |
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| 期刊信息：《中国骨伤》2013年，第26卷，第9期，第764-767页 |
| DOI：10.3969/j.issn.1003-0034.2013.09.015 |
| 基金项目: |
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中文摘要:
目的：通过建立胶原诱导性关节炎(collagen inducted arthritis,CIA)大鼠模型,评价骨碎补总黄酮在抑制CIA大鼠关节骨破坏方面的作用及机制.
方法：利用皮下注射牛Ⅱ型胶原诱导Wistar大鼠发病,建立CIA大鼠模型.将造模成功且炎症分值在2分及以上的大鼠进行随机分组并进行相应治疗,评价骨碎补总黄酮对关节骨破坏情况的作用.
结果：治疗12周后,骨碎补总黄酮组、骨碎补总黄酮加1/2依那西普组、依那西普组骨小梁面积百分数及骨小梁数量均明显高于灭菌用水组(P<0.05);骨小梁分离度明显小于灭菌用水组(P<0.05).
结论：骨碎补总黄酮能明显抑制CIA大鼠炎症关节骨破坏,其作用可能与骨小梁数量减少及骨小梁分离度的增大相关. |
| 【关键词】关节炎,实验性 骨碎补 大鼠 中草药 |
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| Experimental study on effect of Rhizoma Drynariae Flavone on bone destruction of collagen inducted arthritis rat |
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ABSTRACT
Objective：Through establishing the rat model of CIA to evaluate the effect and mechanism of Rhizoma Drynariae Flavone on bone destruction of CIA rat.
Methods：Subcutaneous injection of bovine type Ⅱ coll agen was used to induce Wistar rats to fall ill,and then established the rat model of CIA.The rats whose in flammation scores reached to two points or above were randomly divided into four groups,and were treated a ccordingly.The effect of Rhizoma Drynariae Flavone on bone destruction was evaluated.
Results：At 12 weeks after treatment,bone trabecular area percentage and bone trabecular number in Rhizoma Drynariae Flavone group,Rhizoma Drynariae Flavone-1/2 Etanercept group,Etanercept group was obviously higher than that of sterilization water group (P<0.05);and the trabecular resolving power of these groups was obviously less than that of sterilization water group(P<0.05).
Conclusion：Rhizoma Drynariae Flavone can obviously inhibit inflammation of joint bone destruction of CIA rats,the effect may be related with bone trabecular number reduction and trabecular resolving power increasing. |
| KEY WORDS Arthritis,experimental Drynaria Fortunei Rats Drugs,Chinese herbal |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 高华利,肖涟波,张子峰,欧阳桂林,黄新星,李宁丽,胡军林,黄志明,黄正,解骏.骨碎补总黄酮对胶原诱导性关节炎大鼠关节骨破坏影响的实验研究[J].中国骨伤,2013,26(9):764~767 |
| 英文格式: | GAO Hua-li,XIAO Lian-bo,ZHANG Zi-feng,OUYANG Gui-lin,HUANG Xin-xing,LI Ning-li,HU Jun-lin,HUANG Zhi-ming,HUANG Zheng,XIE Jun.Experimental study on effect of Rhizoma Drynariae Flavone on bone destruction of collagen inducted arthritis rat[J].zhongguo gu shang / China J Orthop Trauma ,2013,26(9):764~767 |
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