| 蛋白质组学在股骨头坏死中的研究进展 |
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投稿时间：2012-05-15
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| 作者 | Author | 单位 | Address | E-Mail |
| 胡淼锋 |
HU Miao-feng |
浙江中医药大学, 浙江 杭州 310053 |
Department of Orthopaedics, Hospital of Traditional Chinese Medicine of Zhejiang Province, Hangzhou, 310053, Zhejiang, China |
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| 周晓成 |
ZHOU Xiao-cheng |
浙江中医药大学, 浙江 杭州 310053 |
Department of Orthopaedics, Hospital of Traditional Chinese Medicine of Zhejiang Province, Hangzhou, 310053, Zhejiang, China |
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| 单乐天 |
SHAN Le-tian |
浙江中医药大学, 浙江 杭州 310053 |
Department of Orthopaedics, Hospital of Traditional Chinese Medicine of Zhejiang Province, Hangzhou, 310053, Zhejiang, China |
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| 肖鲁伟 |
XIAO Lu-wei |
浙江中医药大学, 浙江 杭州 310053 |
Department of Orthopaedics, Hospital of Traditional Chinese Medicine of Zhejiang Province, Hangzhou, 310053, Zhejiang, China |
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| 童培建 |
TONG Pei-jian |
浙江省中医院骨科, 浙江 杭州 310006 |
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tongpeijian@163.com |
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| 期刊信息：《中国骨伤》2013年，第26卷，第3期，第264-266页 |
| DOI：10.3969/j.issn.1003-0034.2013.03.024 |
| 基金项目:国家自然科学基金(编号:81072820) |
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| 中文摘要:蛋白质组学技术的兴起能快速筛选并鉴定疾病的特异性生物标记物,有助于揭示股骨头坏死的发生机制,早期诊断,从而寻找更有效的治疗方法和治疗靶点。目前以找出其发生机制、早期诊断和早期治疗的相关蛋白及其功能鉴定,建立相关数据库及蛋白提取方法的优化为研究热点和焦点。本文综述近年来股骨头坏死相关的蛋白质研究技术及其在股骨头坏死患者骨组织、血清及相关动物模型中运用,为进一步研究提供思路。 |
| 【关键词】股骨头坏死 蛋白质组学 综述文献 |
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| Research progress on proteomics in femur head necrosis |
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| ABSTRACT Appearance of proteomics technology can fleetly filt and reveal specificity biomarkers of disease,this will help to reveal the pathogenesis of femur head necrosis and help early diagnosis,find more effective methods and therapeutic targets. At present,they are hot spots that find out the occurred mechanism,related proteins of early diagnosis and early treatment and its functional identification;set up the early related database; optimize the protein extraction methods for research of femur head necrosis. This article reviews the application of study technology of related proteins of femur head necrosis on bone tissue,serum,related animal model,and in order to provide further research ideas. |
| KEY WORDS Femur head necrosis Proteomics Review literature |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 胡淼锋,周晓成,单乐天,肖鲁伟,童培建.蛋白质组学在股骨头坏死中的研究进展[J].中国骨伤,2013,26(3):264~266 |
| 英文格式: | HU Miao-feng,ZHOU Xiao-cheng,SHAN Le-tian,XIAO Lu-wei,TONG Pei-jian.Research progress on proteomics in femur head necrosis[J].zhongguo gu shang / China J Orthop Trauma ,2013,26(3):264~266 |
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