| 软骨标志物CTX-Ⅱ在骨关节炎中的应用 |
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投稿时间：2012-04-08
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| 作者 | Author | 单位 | Address | E-Mail |
| 王学宗 |
WANG Xue-zong |
上海中医药大学附属曙光医院, 上海 201203 |
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
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| 高宁阳 |
GAO Ning-yang |
上海中医药大学附属曙光医院, 上海 201203 |
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
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| 刘婷 |
LIU Ting |
上海中医药大学附属曙光医院, 上海 201203 |
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
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| 沈军 |
SHEN Jun |
上海中医药大学附属曙光医院, 上海 201203 |
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
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| 韦宋谱 |
WEI Song-pu |
上海中医药大学附属曙光医院, 上海 201203 |
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
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| 郑昱新 |
ZHENG Yu-xin |
上海中医药大学附属曙光医院, 上海 201203 |
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
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| 曹月龙 |
CAO Yue-long* |
上海中医药大学附属曙光医院, 上海 201203
上海市中医药研究院骨伤科研究所, 上海 201203 |
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
ningtcm@126.com |
| 詹红生 |
ZHAN Hong-sheng |
上海中医药大学附属曙光医院, 上海 201203
上海市中医药研究院骨伤科研究所, 上海 201203 |
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
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| 期刊信息：《中国骨伤》2013年，第26卷，第3期，第260-263页 |
| DOI：10.3969/j.issn.1003-0034.2013.03.023 |
| 基金项目:“中医骨伤科学”国家重点学科(编号:100508);国家自然科学基金(编号:81072830,81173277);上海市教委创新项目(编号:11YZ64) |
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| 中文摘要:骨关节炎(OA)的临床诊断尚缺乏有效的生物学标志物。研究证实标志物Ⅱ型胶原羧基端交联肽(CTX-Ⅱ)是关节软骨降解的特异性指标。CTX-Ⅱ检测可及时反映软骨损伤和退变程度、诊断OA发生、预测OA进展和监测药物治疗效果,从而间接反映OA患者的病情。CTX-Ⅱ的应用主要集中于OA早期,并需联合其他生物学标志物一起检测,以便更准确的反映OA病变,但其检测结果具体临床指导意义还需进一步完善。 |
| 【关键词】骨关节炎 软骨 综述文献 |
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| Application of biomarker CTX-Ⅱ in osteoarthritis |
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| ABSTRACT Effective biomarkers for clinical usage of osteoarthritis are still limited. It was confirmed that C-terminal crosslinking telopeptide of typeⅡcollagen (CTX-Ⅱ) was a specific marker reflecting degradation of articular cartilage. Detection of CTX-Ⅱ could promptly reflect level of cartilage injury and degradation,diagnose OA,predict its progress,monitor effects of drug treatment,thus,reflect the condition of osteoarthritis patient indirectly. Application of CTX-Ⅱ focused mainly on in the early stage of OA and need together to detect with other biomarkers,in order to more accurately reflection of the pathological changes of OA,but the specific clinical significance of CTX-Ⅱ results still need to improve further. |
| KEY WORDS Osteoarthritis Cartilage Review literature |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 王学宗,高宁阳,刘婷,沈军,韦宋谱,郑昱新,曹月龙,詹红生.软骨标志物CTX-Ⅱ在骨关节炎中的应用[J].中国骨伤,2013,26(3):260~263 |
| 英文格式: | WANG Xue-zong,GAO Ning-yang,LIU Ting,SHEN Jun,WEI Song-pu,ZHENG Yu-xin,CAO Yue-long*,ZHAN Hong-sheng.Application of biomarker CTX-Ⅱ in osteoarthritis[J].zhongguo gu shang / China J Orthop Trauma ,2013,26(3):260~263 |
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